Tumor-infiltrating monocytic myeloid-derived suppressor cells mediate CCR5-dependent recruitment of regulatory T cells favoring tumor growth
E Schlecker, A Stojanovic, C Eisen… - The Journal of …, 2012 - journals.aai.org
Myeloid-derived suppressor cells (MDSCs) represent a heterogeneous population of
myeloid cells in cancer patients and tumor-bearing mice that potently inhibits T cell …
myeloid cells in cancer patients and tumor-bearing mice that potently inhibits T cell …
Monocytic CCR2+ Myeloid-Derived Suppressor Cells Promote Immune Escape by Limiting Activated CD8 T-cell Infiltration into the Tumor Microenvironment
Myeloid-derived suppressor cells (MDSC) are a heterogeneous population of cells that
accumulate during tumor formation, facilitate immune escape, and enable tumor …
accumulate during tumor formation, facilitate immune escape, and enable tumor …
CCR5+ Myeloid-Derived Suppressor Cells Are Enriched and Activated in Melanoma Lesions
C Blattner, V Fleming, R Weber, B Himmelhan… - Cancer research, 2018 - AACR
Accumulation of myeloid-derived suppressor cells (MDSC) in melanoma microenvironment
is supported by chemokine receptor/chemokine signaling. Although different chemokines …
is supported by chemokine receptor/chemokine signaling. Although different chemokines …
CCR5 in recruitment and activation of myeloid-derived suppressor cells in melanoma
V Umansky, C Blattner, C Gebhardt, J Utikal - Cancer Immunology …, 2017 - Springer
Malignant melanoma is characterized by the development of chronic inflammation in the
tumor microenvironment, leading to the accumulation of myeloid-derived suppressor cells …
tumor microenvironment, leading to the accumulation of myeloid-derived suppressor cells …
Chemokine-mediated rapid turnover of myeloid-derived suppressor cells in tumor-bearing mice
Y Sawanobori, S Ueha, M Kurachi… - Blood, The Journal …, 2008 - ashpublications.org
Tumor growth is associated with aberrant myelopoiesis, including the accumulation of
CD11b+ Gr-1+ myeloid-derived suppressor cells (MDSCs) that have the potential to promote …
CD11b+ Gr-1+ myeloid-derived suppressor cells (MDSCs) that have the potential to promote …
CCR8 marks highly suppressive Treg cells within tumours but is dispensable for their accumulation and suppressive function
SK Whiteside, FM Grant, DS Gyori, AG Conti… - …, 2021 - Wiley Online Library
Abstract CD4+ regulatory T (Treg) cells, dependent upon the transcription factor Foxp3,
contribute to tumour immunosuppression but are also required for immune homeostasis …
contribute to tumour immunosuppression but are also required for immune homeostasis …
[HTML][HTML] Inhibiting myeloid-derived suppressor cell trafficking enhances T cell immunotherapy
L Sun, PE Clavijo, Y Robbins, P Patel, J Friedman… - JCI insight, 2019 - ncbi.nlm.nih.gov
Recruitment of myeloid-derived suppressor cells (MDSCs) into tumors induces local
immunosuppression in carcinomas. Here, we assessed whether SX-682, an orally …
immunosuppression in carcinomas. Here, we assessed whether SX-682, an orally …
CCL2/CCR2 pathway mediates recruitment of myeloid suppressor cells to cancers
B Huang, Z Lei, J Zhao, W Gong, J Liu, Z Chen, Y Liu… - Cancer letters, 2007 - Elsevier
In addition to direct effect on tumor cells, the tumor-promoting activity of CCL2 has been
ascribed to its role in chemoattracting tumor-associated macrophages. However it is unclear …
ascribed to its role in chemoattracting tumor-associated macrophages. However it is unclear …
[HTML][HTML] Ex vivo generation of myeloid-derived suppressor cells that model the tumor immunosuppressive environment in colorectal cancer
Myeloid-derived suppressor cells (MDSC) are a heterogeneous population of cells that
accumulate in tumor-bearing subjects and which strongly inhibit anti-cancer immune …
accumulate in tumor-bearing subjects and which strongly inhibit anti-cancer immune …
Identification of discrete tumor-induced myeloid-derived suppressor cell subpopulations with distinct T cell–suppressive activity
K Movahedi, M Guilliams… - Blood, The Journal …, 2008 - ashpublications.org
The induction of CD11b+ Gr-1+ myeloid-derived suppressor cells (MDSCs) is an important
immune-evading mechanism used by tumors. However, the exact nature and function of …
immune-evading mechanism used by tumors. However, the exact nature and function of …