Differential effects of cognitive reserve and brain reserve on cognition in Alzheimer disease

C Groot, AC van Loenhoud, F Barkhof… - Neurology, 2018 - AAN Enterprises
Objective To examine cross-sectional effects of cognitive reserve (CR) and brain reserve
(BR) on cognition across the spectrum of Alzheimer disease (AD). Methods We included 663 …

Cognitive reserve and clinical progression in Alzheimer disease: a paradoxical relationship

AC van Loenhoud, WM van der Flier, AM Wink… - Neurology, 2019 - AAN Enterprises
Objective To investigate the relationship between cognitive reserve (CR) and clinical
progression across the Alzheimer disease (AD) spectrum. Methods We selected 839 β …

Effects of cognitive reserve depend on executive and semantic demands of the task

RR Darby, M Brickhouse, DA Wolk… - Journal of Neurology …, 2017 - jnnp.bmj.com
Background Cognitive reserve (CR) is one factor that helps to maintain cognitive function in
patients with Alzheimer's disease (AD). Whether the effects of CR depend on the …

The dual role of cognitive reserve in subjective cognitive decline and mild cognitive impairment: a 7-year follow-up study

S Mazzeo, S Padiglioni, S Bagnoli, L Bracco… - Journal of …, 2019 - Springer
The aim of this study was to evaluate the effect of cognitive reserve (CR), in progression from
subjective cognitive decline (SCD) to mild cognitive impairment (MCI) and Alzheimer's …

Cognitive reserve modulates attention processes in healthy elderly and amnestic mild cognitive impairment: An event-related potential study

L Gu, J Chen, L Gao, H Shu, Z Wang, D Liu, Y Yan… - Clinical …, 2018 - Elsevier
Objectives The study aimed to investigate and compare the effect of cognitive reserve (CR)
on brain activation in healthy controls (HC) and amnestic mild cognitive impairment (aMCI) …

Influence of cognitive reserve on cognitive trajectories: role of brain pathologies

X Li, R Song, X Qi, H Xu, W Yang, M Kivipelto… - Neurology, 2021 - AAN Enterprises
Background and Objectives Evidence on the association of cognitive reserve (CR) with the
cognitive trajectories is limited. We aimed to examine the influence of CR indicator on …

Effects of cognitive reserve in Alzheimer's disease and cognitively unimpaired individuals

DH Lee, SW Seo, JH Roh, M Oh, JS Oh… - Frontiers in Aging …, 2022 - frontiersin.org
The concept of cognitive reserve (CR) has been proposed as a protective factor that
modifies the effect of brain pathology on cognitive performance. It has been characterized …

Effect of cognitive reserve markers on Alzheimer pathologic progression

RY Lo, WJ Jagust… - Alzheimer Disease & …, 2013 - journals.lww.com
Education, occupation, premorbid intelligence, and brain size are surrogate markers for
cognitive reserve. Whether these markers have biological influence on Alzheimer disease …

A neuroimaging approach to capture cognitive reserve: application to Alzheimer's disease

AC van Loenhoud, AM Wink, C Groot… - Human brain …, 2017 - Wiley Online Library
Cognitive reserve (CR) explains interindividual differences in the ability to maintain cognitive
function in the presence of neuropathology. We developed a neuroimaging approach …

Effect of cognitive reserve on age-related changes in cerebrospinal fluid biomarkers of Alzheimer disease

RP Almeida, SA Schultz, BP Austin, EA Boots… - JAMA …, 2015 - jamanetwork.com
Importance Although advancing age is the strongest risk factor for the development of
symptomatic Alzheimer disease (AD), recent studies have shown that there are individual …