It has been reported that remarkable and sustained activation of astrocytes and/or microglia
occurs in cancer induced pain (CIP), which is different from neuropathic and inflammatory …

Molecular mechanisms underlying bone cancer pain are poorly understood. Recently, p38
mitogen-activated protein kinase (MAPK) activation was shown to play a major role not only …

Bone cancer pain (BCP) is one of the most difficult and intractable tasks for pain
management, which is associated with spinal 'neuron-astrocytic'activation. The activation of …

Studies suggest that astrocytes and microglia in the spinal cord are involved in the
development of persistent pain induced by tissue inflammation and nerve injury. However …

Activation of spinal cord microglia and astrocytes is a common phenomenon in nerve injury
pain models and is thought to exacerbate pain perception. Following a nerve injury, a …

It has been reported that Toll-like receptor 4 (TLR4), which plays an important role in glial
activation in neuropathic pain, is significantly increased in cancer pain. The present study …

Background: Tumor compression-induced pain (TCIP) is a complex pathological cancer
pain. Spinal glial cells play a critical role in maintenance of cancer pain by releasing …

Accumulating evidence suggests that activation of spinal microglia contributes to the
development of inflammatory and neuropathic pain. However, the role of spinal microglia in …

After spinal cord injury (SCI), the control of activated glial cells such as microglia and
astrocytes has emerged as a promising strategy for neuropathic pain management …

Our previous study indicated that coadministration of tramadol and minocycline exerted
synergistic effects on spinal nerve ligation (SNL)-induced neuropathic mechanical allodynia …