Level of IL-6, TNF, and IL-1β and age-related diseases: a systematic review and meta-analysis

A Tylutka, Ł Walas, A Zembron-Lacny - Frontiers in Immunology, 2024 - frontiersin.org
Introduction Chronic low-grade inflammation is an important aspect of morbidity and
mortality in older adults. The level of circulating pro-inflammatory cytokines (interleukin (IL) …

Circulating interleukin-6 levels and cardiovascular and all-cause mortality in the elderly population: a meta-analysis

H Li, W Liu, J Xie - Archives of Gerontology and Geriatrics, 2017 - Elsevier
Objective: Inflammatory markers may be associated with mortality in the elderly population.
We conducted this meta-analysis to evaluate the association of elevated circulating …

IL-1β, IL-6, TNF-α and CRP in elderly patients with depression or Alzheimer's disease: systematic review and meta-analysis

A Ng, WW Tam, MW Zhang, CS Ho, SF Husain… - Scientific reports, 2018 - nature.com
We carried out systematic review and meta-analysis to evaluate whether peripheral levels of
pro-inflammatory markers including Interleukin-1 beta (IL-1β), Interleukin-6 (IL-6), Tumor …

Plasma cytokine levels in a population-based study: relation to age and ethnicity

RP Stowe, MK Peek, MP Cutchin… - Journals of Gerontology …, 2010 - academic.oup.com
Background Aging is one factor believed to contribute to processes that underlie chronic low-
grade inflammation in older adults. Moreover, more recent studies have suggested that …

The clinical importance of proinflammatory cytokines in elderly populations

H Bruunsgaard, K Krabbe - NeuroImmune Biology, 2004 - Elsevier
Low-grade increases in the plasma level of inflammatory mediators are related to age-
associated pathology including cardiovascular diseases, dementia and sarcopenia …

Cytokines for evaluation of chronic inflammatory status in ageing research: reliability and phenotypic characterisation

L Koelman, O Pivovarova-Ramich, AFH Pfeiffer… - Immunity & …, 2019 - Springer
Background There is a growing interest in the role of inflammageing for chronic disease
development. Cytokines are potent soluble immune mediators that can be used as target …

Increased basal and alum-induced interleukin-6 levels in geriatric patients are associated with cardiovascular morbidity

N Compté, KZ Boudjeltia, M Vanhaeverbeek… - Plos one, 2013 - journals.plos.org
Background/Aim of the study Low-grade systemic inflammation was suggested to participate
to the decline of physiological functions and increased vulnerability encountered in older …

Effects of tumor necrosis factor-alpha and interleukin-6 in elderly populations

H Bruunsgaard - European Cytokine Network, 2003 - jle.com
Aging is associated with low-grade increases in circulating levels of TNF-a and IL-6. A wide
range of factors, including smoking, obesity, infections, the decline in sex hormones, and the …

Predicting death from tumour necrosis factor-alpha and interleukin-6 in 80-year-old people

H Bruunsgaard, S Ladelund… - Clinical & …, 2003 - academic.oup.com
Ageing is associated with low-grade inflammation and markers such as IL-6 possess
prognostic value. Tumour necrosis-alpha (TNF-α) initiates the inflammatory cascade and …

[HTML][HTML] Inflammation and frailty in the elderly: a systematic review and meta-analysis

P Soysal, B Stubbs, P Lucato, C Luchini, M Solmi… - Ageing research …, 2016 - Elsevier
The pathogenesis of frailty and the role of inflammation is poorly understood. We examined
the evidence considering the relationship between inflammation and frailty through a …