Specific cell populations may have unique contributions to schizophrenia but may be missed
in studies of homogenate tissue. Here laser capture microdissection followed by RNA …

Mounting evidence suggests that function and connectivity of the striatum is disrupted in
schizophrenia,,,–. We have developed a new hypothesis-driven neuroimaging biomarker for …

Over 100 associated genetic loci have been robustly associated with schizophrenia. Gene
prioritization and pathway analysis have focused on a priori hypotheses and thus may have …

Schizophrenia is thought to be a multifactorial disease with complex mode of inheritance1,
2. Using a two-stage strategy for another complex disorder, a number of putative IDDM …

To identify susceptibility loci for schizophrenia, we performed a two-stage genome-wide
association study (GWAS) of schizophrenia in the Han Chinese population (GWAS: 746 …

Genome-wide association studies have identified 108 schizophrenia risk loci, but biological
mechanisms for individual loci are largely unknown. Using developmental, genetic and …

Schizophrenia, a devastating psychiatric disorder, has a prevalence of 0.5–1%, with high
heritability (80–85%) and complex transmission. Recent studies implicate rare, large, high …

Transcriptomic imputation approaches combine eQTL reference panels with large-scale
genotype data in order to test associations between disease and gene expression. These …

As technology advances, whole genome sequencing (WGS) is likely to supersede other
genotyping technologies. The rate of this change depends on its relative cost and utility …

Large-scale genomic studies of schizophrenia have identified hundreds of genetic loci
conferring risk to the disorder. This progress offers an important route toward defining the …