Sarcopenia: age-related skeletal muscle changes from determinants to physical disability

A Di Iorio, M Abate, D Di Renzo… - International journal …, 2006 - journals.sagepub.com
Human aging is characterized by skeletal muscle wasting, a debilitating condition which sets
the susceptibility for diseases that directly affect the quality of life and often limit life span …

The contribution of starvation, deconditioning and ageing to the observed alterations in peripheral skeletal muscle in chronic organ diseases

FME Franssen, EFM Wouters, AMWJ Schols - Clinical Nutrition, 2002 - Elsevier
Muscle weakness and early fatigue are common symptoms of chronic organ diseases, like
chronic obstructive pulmonary disease (COPD), chronic heart failure (CHF) and chronic …

Effects of aging on muscle fibre type and size

MR Deschenes - Sports medicine, 2004 - Springer
Aging has been associated with a loss of muscle mass that is referred to as 'sarcopenia'.
This decrease in muscle tissue begins around the age of 50 years, but becomes more …

[HTML][HTML] Significance of sarcopenia in the elderly

C Dutta - The Journal of nutrition, 1997 - Elsevier
At the present time, there is only limited understanding of the public health significance of
sarcopenia. The well-recognized functional consequences of sarcopenia include gait and …

Physiopathological mechanism of sarcopenia

S Walrand, C Guillet, J Salles… - Clinics in geriatric …, 2011 - geriatric.theclinics.com
Muscle erosion, which begins after the age of 55 years, is one of the most important factors
of disability in elderly people. The cumulative decline in muscle mass reaches 40% from 20 …

Skeletal muscle power: a critical determinant of physical functioning in older adults

KF Reid, RA Fielding - Exercise and sport sciences reviews, 2012 - journals.lww.com
Muscle power declines earlier and more precipitously with advancing age compared with
muscle strength. Peak muscle power also has emerged as an important predictor of …

Development of physical disability in older adults

T Manini - Current aging science, 2011 - ingentaconnect.com
Demographers expect the number of older persons to double to 86.7 million—or to 20.6% of
the US population—by the year 2050. As has occurred over the past decade, the health care …

Current understanding of sarcopenia: possible candidates modulating muscle mass

K Sakuma, W Aoi, A Yamaguchi - Pflügers Archiv-European Journal of …, 2015 - Springer
The world's elderly population is expanding rapidly, and we are now faced with the
significant challenge of maintaining or improving physical activity, independence, and …

A neuromuscular perspective of sarcopenia pathogenesis: Deciphering the signaling pathways involved

A Moreira-Pais, R Ferreira, PA Oliveira, JA Duarte - Geroscience, 2022 - Springer
The escalation of life expectancy is accompanied by an increase in the prevalence of age-
related conditions, such as sarcopenia. Sarcopenia, a muscle condition defined by low …

Human skeletal muscle disuse atrophy: effects on muscle protein synthesis, breakdown, and insulin resistance—a qualitative review

SS Rudrappa, DJ Wilkinson, PL Greenhaff… - Frontiers in …, 2016 - frontiersin.org
The ever increasing burden of an aging population and pandemic of metabolic syndrome
worldwide demands further understanding of the modifiable risk factors in reducing disability …