Toll-like receptors (TLRs) are pivotal in triggering the innate immune response to pathogen
infection. Ligand binding induces receptor dimerization which facilitates the recruitment of …

Toll-like receptors (TLRs) form part of the host innate immune system, in which they act as
sensors of microbial and endogenous danger signals. Upon TLR activation, the intracellular …

Members of the Toll-like receptor and interleukin-1 (IL-1) receptor families all signal via
Toll/IL-1R (TIR) domain-driven assemblies with adaptors such as MyD88. We here combine …

Toll-like receptors (TLRs) mediate responses to pathogen-associated molecules as part of
the vertebrate innate immune response to infection. Receptor dimerization is coupled to …

Innate immune receptors detect microbial pathogens and subsequently activate adaptive
immune responses to combat pathogen invasion. MyD88 is a key adaptor molecule in both …

Myeloid differentiation factor 88 (MyD88) is an adaptor protein that transduces intracellular
signaling pathways evoked by the Toll-like receptors (TLRs) and interleukin-1 receptors (IL …

Myeloid differentiating factor 88 (MyD88) and MyD88 adaptor-like (Mal) are adaptor
molecules critically involved in the Toll-like receptor (TLR) 4 signaling pathway. While Mal …

MyD88 is a cytoplasmic adaptor protein that is critical for Toll-like receptor (TLR) signaling.
The subcellular localization of MyD88 is characterized as large condensed forms in the …

TLRs are expressed on the plasma and endosomal membranes of innate immune cells
acting as sensors of foreign and inherent danger signals that threaten the host. Upon …

Toll-like receptors (TLRs) and members of the proinflammatory interleukin 1 receptor (IL-1R)
family are dependent on the presence of MyD88 for efficient signal transduction. The …