Developing safe and effective double-stranded RNA (dsRNA) delivery systems remains a
major challenge for gene silencing, especially in lepidopteran insects. This study evaluated …

Developing strategies to optimize double-stranded RNA (dsRNA) delivery remains a
significant challenge in improving RNA interference (RNAi) in insects. Nanoformulations …

This work focused on the delivery of dsRNA either complexed with poly-l-arginine (PLR-
polyplex) or loaded onto poly-l-arginine functionalized 20 nm Au nanoparticles (PLR/Au …

Conventional synthetic insecticides have limited success due to insect resistance and
negative effects on off-target biota and the environment. Although RNA interference (RNAi) …

RNA interference (RNAi) has become an essential technique in functional analysis of insect
genes and pest management. However, insensitivity to RNAi is the main obstacle that limits …

The low efficiency of RNA interference (RNAi) in insects via the oral administration of double-
stranded RNA (dsRNA) is a considerable obstacle preventing its application in insect pest …

In recent years, the use of non-viral vectors to deliver genes or drugs has become more and
more attractive due to their higher safety and ease of mass production. The most common …

RNA interference (RNAi) targeting lethal genes in insects has great potential for sustainable
crop protection. Compared with traditional double‐stranded (ds) RNA delivery systems …

The spotted bollworm Earias vittella (Lepidoptera: Nolidae) is a polyphagous pest with
enormous economic significance, primarily affecting cotton and okra. However, the lack of …

BACKGROUND It is difficult to efficiently silence gene expression in some insects, probably
because of the degradation of dsRNA by enzymes present in the gut and hemolymph post …