Radiotherapy in the presence of contrast agents: a general figure of merit and its application to gold nanoparticles

SJ McMahon, MH Mendenhall, S Jain… - Physics in Medicine & …, 2008 - iopscience.iop.org
Delivering sufficient dose to tumours while sparing surrounding tissue is one of the primary
challenges of radiotherapy, and in common practice this is typically achieved by using highly …

Contrast-enhanced radiotherapy: feasibility and characteristics of the physical absorbed dose distribution for deep-seated tumors

HM Garnica-Garza - Physics in Medicine & Biology, 2009 - iopscience.iop.org
Radiotherapy using kilovoltage x-rays in conjunction with contrast agents incorporated into
the tumor, gold nanoparticles in particular, could represent a potential alternative to current …

Enhancement of radiation effects by gold nanoparticles for superficial radiation therapy

WN Rahman, N Bishara, T Ackerly… - Nanomedicine in …, 2017 - api.taylorfrancis.com
Radiation therapy aims to deliver a high therapeutic dose of ionizing radiation to the tumor
volume without exceeding normal tissue tolerance. Preferential tumor uptake of contrast …

Estimation of tumour dose enhancement due to gold nanoparticles during typical radiation treatments: a preliminary Monte Carlo study

SH Cho - Physics in Medicine & Biology, 2005 - iopscience.iop.org
A recent mice study demonstrated that gold nanoparticles could be safely administered and
used to enhance the tumour dose during radiation therapy. The use of gold nanoparticles …

Nanoparticle radio-enhancement: principles, progress and application to cancer treatment

Z Kuncic, S Lacombe - Physics in Medicine & Biology, 2018 - iopscience.iop.org
Enhancement of radiation effects by high-atomic number nanoparticles (NPs) has been
increasingly studied for its potential to improve radiotherapeutic efficacy. The underlying …

Beam energy considerations for gold nano-particle enhanced radiation treatment

F Van den Heuvel, JP Locquet… - Physics in Medicine & …, 2010 - iopscience.iop.org
A novel approach using nano-technology enhanced radiation modalities is investigated. The
proposed methodology uses antibodies labeled with organically inert metals with a high …

Gold nanoparticles and their alternatives for radiation therapy enhancement

DR Cooper, D Bekah, JL Nadeau - Frontiers in chemistry, 2014 - frontiersin.org
Radiation therapy is one of the most commonly used treatments for cancer. The dose of
delivered ionizing radiation can be amplified by the presence of high-Z materials via an …

Nanodosimetric effects of gold nanoparticles in megavoltage radiation therapy

SJ McMahon, WB Hyland, MF Muir, JA Coulter… - Radiotherapy and …, 2011 - Elsevier
BACKGROUND AND PURPOSE: The addition of gold nanoparticles (GNPs) to tumours
leads to an increase in dose due to their high density and energy absorption coefficient …

Gold nanoparticles in radiotherapy and recent progress in nanobrachytherapy

M Laprise‐Pelletier, T Simão… - Advanced healthcare …, 2018 - Wiley Online Library
Over the last few decades, gold nanoparticles (GNPs) have emerged as “radiosensitizers” in
oncology. Radiosensitizers are additives that can enhance the effects of radiation on …

The dosimetric feasibility of gold nanoparticle-aided radiation therapy (GNRT) via brachytherapy using low-energy gamma-/x-ray sources

SH Cho, BL Jones, S Krishnan - Physics in Medicine & Biology, 2009 - iopscience.iop.org
The preferential accumulation of gold nanoparticles within tumors and the increased
photoelectric absorption due to the high atomic number of gold cooperatively account for the …