Computational modeling has advanced our understanding of drug absorption, tissue
distribution, excretion and toxicity profiles by providing both direct and indirect knowledge of …

We have seen an increased use of computational approaches to predicting drug interactions
with human transporters that affect drug disposition and may lead to toxicity. These …

Transport proteins are important mediators of cellular drug influx and efflux and play crucial
roles in drug distribution, disposition and clearance. Drug-drug interactions have …

Transporter proteins are expressed throughout the human body in different vital organs.
They play an important role to various extents in determining absorption, distribution …

Membrane transporters play a key role in the absorption, distribution, clearance, elimination,
and transport of drugs. Understanding the drug properties and structure activity relationships …

Physiologically based pharmacokinetic modeling is a commonly used strategy in the drug
development and regulatory submissions. This commentary provides a critical overview of …

Membrane transporters play an important role in intestinal absorption, distribution and
clearance of drugs. Additionally transporters along with enzymes regulate tissue exposures …

Transporters play an important role in drug absorption, disposition, and drug action. The
evaluation of drug transporters requires a comprehensive understanding of transporter …

The past few years have ushered in a wealth of new information on transporter biology,
ranging from the publication of new crystal structures of the human glucose transporters …

Since the late 1980s computational methods such as quantitative structure–activity
relationship (QSAR) and pharmacophore approaches have become more widely applied to …