The most promising strategies in bone engineering have concentrated on providing
sufficient vascularization to support the newly forming tissue. In this context, recent research …

Vascularization is important for bone development, fracture healing and engineering of
artificial bone tissue. In the context of bone tissue engineering, it was shown that …

Coculturing of bone‐forming and blood vessel‐forming cells is a strategy aimed at
increasing vascularity of implanted bone constructs in tissue‐engineering applications. We …

Osteogenesis occurs in striking interaction with angiogenesis. There is growing evidence
that endothelial cells are involved in the modulation of osteoblast differentiation. We …

Creating a functional vascularized bone tissue remains one of the main goals of bone tissue
engineering. Recently, a growing interest in the crosstalk between endothelial cells (EC) …

Bone development and remodeling depend on complex interactions between bone-forming
osteoblasts and other cells present within the bone microenvironment, particularly …

Multipotent adult stem cells/precursor cells, especially of the mesenchymal and endothelial
lineage, may have great potential for bone tissue engineering. Although their potential is …

Proper bone remodeling requires an active process of angiogenesis which in turn supplies
the necessary growth factors and stem cells. This tissue cooperation suggests a cross‐talk …

Background A dynamic vasculature is a prerequisite for bone formation where the
interaction of bone cells and endothelial cells is essential for both the development and the …

The repair of bone defects caused by trauma, infection or tumor resection is a major clinical
orthopedic challenge. The application of bone grafts in orthopedic procedures is associated …