Cannabidiol anticonvulsant effect is mediated by the PI3Kγ pathway

IV de Assis Lima, PMQ Bellozi, EM Batista, LR Vilela… - …, 2020 - Elsevier
Abstract The phosphatidylinositol 3-kinase (PI3K)/protein kinase B (PKB/Akt)/mechanistic
target of rapamycin (mTOR) signaling pathway has been associated with several …

Protective effects of cannabidiol against seizures and neuronal death in a rat model of mesial temporal lobe epilepsy

RA Do Val-da Silva, JE Peixoto-Santos… - Frontiers in …, 2017 - frontiersin.org
The present study reports the behavioral, electrophysiological, and neuropathological
effects of cannabidiol (CBD), a major non-psychotropic constituent of Cannabis sativa, in the …

Anticonvulsant effect of cannabidiol in the pentylenetetrazole model: Pharmacological mechanisms, electroencephalographic profile, and brain cytokine levels

LR Vilela, IV Lima, ÉB Kunsch, HPP Pinto… - Epilepsy & Behavior, 2017 - Elsevier
Cannabidiol (CBD), the main nonpsychotomimetic compound from Cannabis sativa, inhibits
experimental seizures in animal models and alleviates certain types of intractable epilepsies …

[HTML][HTML] Cannabidiol inhibits microglia activation and mitigates neuronal damage induced by kainate in an in-vitro seizure model

E Landucci, C Mazzantini, D Lana, M Calvani… - Neurobiology of …, 2022 - Elsevier
Background Epilepsy is one of the most common brain disorder and, despite the possible
use of several therapeutic options, many patients continue to have seizures for their entire …

Cannabidiol Anticonvulsant Effects Against Lithium-Pilocarpine-Induced Status Epilepticus in Male Rats Are Mediated by Neuroinflammation Modulation and …

M Masoumi, MA Manavi… - Cannabis and …, 2024 - liebertpub.com
Background: Status epilepticus (SE) is a series of seizures that can lead to serious
neurological damages. Cannabidiol (CBD) is extracted from the cannabis plant, which has …

Cannabidiol exerts antiepileptic effects by restoring hippocampal interneuron functions in a temporal lobe epilepsy model

AA Khan, T Shekh‐Ahmad, A Khalil… - British journal of …, 2018 - Wiley Online Library
Background and Purpose A non‐psychoactive phytocannabinoid, cannabidiol (CBD), shows
promising results as an effective potential antiepileptic drug in some forms of refractory …

The anticonvulsant effects of cannabidiol in experimental models of epileptic seizures: From behavior and mechanisms to clinical insights

W Lazarini-Lopes, RA Do Val-da Silva… - Neuroscience & …, 2020 - Elsevier
Epilepsy is a neurological disorder characterized by the presence of seizures and
neuropsychiatric comorbidities. Despite the number of antiepileptic drugs, one-third of …

The role of potassium BK channels in anticonvulsant effect of cannabidiol in pentylenetetrazole and maximal electroshock models of seizure in mice

Z Shirazi-Zand, L Ahmad-Molaei, F Motamedi… - Epilepsy & Behavior, 2013 - Elsevier
Cannabidiol is a nonpsychoactive member of phytocannabinoids that produces various
pharmacological effects that are not mediated through putative CB1/CB2 cannabinoid …

Biochemical aspects and therapeutic mechanisms of cannabidiol in epilepsy

APA Boleti, BEF Frihling, PS e Silva… - Neuroscience & …, 2022 - Elsevier
Epilepsy is a chronic neurological disease characterized by recurrent epileptic seizures.
Studies have shown the complexity of epileptogenesis and ictogenesis, in which …

Anticonvulsant action and long-term effects of chronic cannabidiol treatment in the rat pentylenetetrazole-kindling model of epilepsy

Z Gáll, K Kelemen, A Tolokán, I Zolcseak, I Sável… - Biomedicines, 2022 - mdpi.com
Cannabidiol (CBD) showed anticonvulsant action in several preclinical models and is
currently approved by regulatory agencies to treat childhood epilepsy syndromes. However …