Whole-genome or genome-wide association studies have become a fundamental part of
modern genetic studies and methods for dissecting the genetic architecture of common traits …

Genome-wide association studies (GWAS) have emerged as the method of choice for
identifying common variants affecting complex disease. In a GWAS, particular attention is …

Background Growing interest and burgeoning technology for discovering genetic
mechanisms that influence disease processes have ushered in a flood of genetic …

Genome-wide association studies (GWAS) are a powerful tool for investigators to examine
the human genome to detect genetic risk factors, reveal the genetic architecture of diseases …

Understanding underlying mechanisms of common diseases is one of the major goals of
current research in medicine. As most of these disorders are linked to genetic factors …

Sequence data (eg, nucleotides or amino-acids) are critical for advancing our understanding
of biology. However, there are many challenges with investigating and analyzing …

Genetic analysis of complex diseases demands novel analytical methods to interpret data
collected on thousands of variables by genome-wide association studies. The complexity of …

Gene-based association analysis is an effective gene-mapping tool. Many gene-based
methods have been proposed recently. However, their power depends on the underlying …

Motivation Genome wide association studies (GWAS) are extensively used across species
to identify genes that underlie important traits. Most GWAS methods apply modifications and …

Background Genome-wide association studies (GWAS) have become a mainstay of
biological research concerned with discovering genetic variation linked to phenotypic traits …