Chiral allenes, which exist widely in natural products, bioactive pharmaceuticals, and
advanced functional materials, have received considerable attention from chemists. They …

Allene moieties with axial chirality are featured in many natural products with biological
activities. They also serve as unique building blocks in organic synthesis and as chiral …

Asymmetric organocatalysis is a growing method for the synthesis of axially chiral
tetrasubstituted allenes, the most challenging one among allene syntheses. In this method …

Axially chiral allenes occur on a wide range of natural products and synthetic molecules with
significant biological activity. Furthermore, they are versatile building blocks in organic …

The conventional procedures for preparing optically active axially chiral allenes generally
require stoichiometric chiral sources as either substrates or reagents. On the other hand …

The increasing synthetic utility of allenes in organic synthesis combined with their
incorporation into a growing list of natural products and active pharmaceutical ingredients …

An efficient bimetallic Zn (II)/Cu (I)-mediated asymmetric synthesis of simple axially chiral
allenes from terminal alkynes and aldehydes was realized by taking advantage of the chiral …

Chiral allene and N-heteroaryl motifs are present in an ever-growing list of biologically
active natural products and synthetic drugs. Although significant progress has been made in …

While one-carbon central chirality of organic molecules has been recognized and
extensively studied for more than a century, far less attention has been paid to three-carbon …

The general enantioselective synthesis of axially chiral disubstituted allenes from prochiral
starting materials remains a long-standing challenge in organic synthesis. Here, we report …