We analyzed the clinical features of 25 ovarian cancer patients who were associated with
germ-line mutations of BRCA1 from four site-specific ovarian cancer families and seven …

We analyzed genetic alterations in BRCA1 and BRCA2 genes among 82 ovarian cancer
families in Japan. The clinical characteristics of BRCA-associated ovarian cancer patients …

OBJECTIVES.: Mutations in the BRCA1 and BRCA2 genes predispose women to ovarian
and/or breast cancer. The contribution of BRCA1 and BRCA2 mutations to ovarian cancer in …

Germline mutations in the BRCA1 and BRCA2 genes predispose women to breast and
ovarian cancer. An incidence of 5% and 3.3% respectively has been reported of BRCA1 and …

Background We tested the hypothesis that ovarian cancers associated with germ-line
mutations of BRCA1 have distinct clinical and pathological features as compared with …

Objectives. The aim of the study was to determine the prevalence of BRCA1 and BRCA2
germline mutations among ovarian cancer patients ascertained to have a family history of …

To investigate the putative role of BRCA1, a gene involved in hereditary breast and ovarian
cancer, in sporadic ovarian tumors among Japanese women, we examined 76 unselected …

The breast and ovarian cancer susceptibility gene BRCA2 has recently been isolated. A role
for BRCA2 in sporadic breast and ovarian cancer has been suggested by loss of …

Germline mutations in the BRCA1 tumor suppressor gene are thought to be the most
common cause of hereditary ovarian cancer. The aim of this study was to explore further the …

Background Inherited mutations in the BRCA1 gene confer a high risk of breast and ovarian
cancer in some families. To determine the contribution of BRCA1 mutations to ovarian …