Individuals carrying germline mutations in one allele of the BRCA1 or BRCA2 genes are at
significantly increased risk of developing cancer. Although the increased risk of breast …

The breast cancer susceptibility genes, BRCA1 and BRCA2, differ in their contribution to
ovarian cancer. Recently, founder mutations in each of these genes were identified in …

BRCA1 is a tumor suppressor gene that, when mutated, is associated with the development
of hereditary ovarian cancer. A role for BRCA1 in the pathoetiology of sporadic ovarian …

Several BRCA1 mutations have now been found to occur in geographically diverse breast
and ovarian cancer families. To investigate mutation origin and mutation-specific …

The objective of this study was to determine the prevalence of BRCA1 and BRCA2 gene
mutations in unselected ovarian cancer patients, and to analyse clinical and pathological …

Purpose: Several studies to date have reported ovarian cancer risk due to inherited BRCA1
and BRCA2 mutations using familial data or population-based series of probands. Familial …

Several BRCA2 mutations are found to occur in geographically diverse breast and ovarian
cancer families. To investigate both mutation origin and mutation-specific phenotypes due to …

Germline mutations of the BRCA1 tumor suppressor gene on chromosome 17q are involved
in a significant fraction of hereditary breast and ovarian cancers. Allelic deletions that …

An account of familial aggregation in breast/ovarian cancer has become possible with the
identification of BRCA1 germ-line mutations. We evaluated, for 249 individuals registered …

Purpose: Germline mutations in the BRCA1 and BRCA2 genes confer increased
susceptibility to ovarian cancer. There is evidence that tumors in carriers may exhibit a …