Alzheimer's disease (AD) is a debilitating neurodegenerative disorder affecting millions of
elderly individuals worldwide. Advances in the genetics of AD have led to new levels of …

Here, we report proteomic analyses of 129 human cortical tissues to define changes
associated with the asymptomatic and symptomatic stages of Alzheimer's disease (AD) …

Alzheimer's disease (AD) is a devastating neurological disorder characterized by changes in
cell-type proportions and consequently marked alterations of the transcriptome. Here we use …

Background Because of its polygenic nature, Alzheimer's disease is believed to be caused
not by defects in single genes, but rather by variations in a large number of genes and their …

Alzheimer's disease (AD) is a neurodegenerative disorder contributing to rapid decline in
cognitive function and ultimately dementia. Most cases of AD occur in elderly and later …

Abstract Background Transcriptional studies suggest Alzheimer's disease (AD) involves
dysfunction of many cellular pathways, including synaptic transmission, cytoskeletal …

Background Alzheimer's disease (AD) is the most common form of dementia, characterized
by progressive cognitive impairment and neurodegeneration. However, despite extensive …

Aging is regarded as a major risk factor for neurodegenerative diseases. Thus, a better
understanding of the similarities between the aging process and neurodegenerative …

The genetics of complex disease produce alterations in the molecular interactions of cellular
pathways whose collective effect may become clear through the organized structure of …

Background Our understanding of the molecular mechanisms underlying Alzheimer's
disease (AD) remains incomplete. Previous studies have revealed that genetic factors …