Could ceramides become the new cholesterol?

SA Summers - Cell metabolism, 2018 - cell.com
The Mayo Clinic recently introduced a diagnostic test that quantifies plasma ceramides in
order to identify patients at risk of major adverse cardiac events. By comparing recent …

Ceramides improve atherosclerotic cardiovascular disease risk assessment beyond standard risk factors

JW Meeusen, LJ Donato, SL Kopecky, VC Vasile… - Clinica Chimica …, 2020 - Elsevier
Ceramides are bioactive lipids that act as secondary messengers for both intra-and inter-
cellular signaling. Elevated plasma concentrations of ceramides are associated with multiple …

Plasma ceramides predict cardiovascular death in patients with stable coronary artery disease and acute coronary syndromes beyond LDL-cholesterol

R Laaksonen, K Ekroos, M Sysi-Aho… - European heart …, 2016 - academic.oup.com
Aims The aim was to study the prognostic value of plasma ceramides (Cer) as
cardiovascular death (CV death) markers in three independent coronary artery disease …

[HTML][HTML] Emerging roles of ceramide in cardiovascular diseases

H Shu, Y Peng, W Hang, N Li, N Zhou… - Aging and …, 2022 - ncbi.nlm.nih.gov
Ceramide is a core molecule of sphingolipid metabolism that causes selective insulin
resistance and dyslipidemia. Research on its involvement in cardiovascular diseases has …

Ceramides and ceramide scores: clinical applications for cardiometabolic risk stratification

M Hilvo, VC Vasile, LJ Donato, R Hurme… - Frontiers in …, 2020 - frontiersin.org
Ceramides are bioactive lipids that have an important role in many cellular functions such as
apoptosis and inflammation. During the past decade emerging clinical data have shown that …

[HTML][HTML] Circulating ceramides as biomarkers of cardiovascular disease: Evidence from phenotypic and genomic studies

KA McGurk, BD Keavney, A Nicolaou - Atherosclerosis, 2021 - Elsevier
There is a need for new biomarkers of atherosclerotic cardiovascular disease (ACVD), the
main cause of death globally. Ceramides, a class of potent bioactive lipid mediators, have …

Circulating ceramides predict cardiovascular outcomes in the population-based FINRISK 2002 cohort

AS Havulinna, M Sysi-Aho, M Hilvo… - … , and vascular biology, 2016 - Am Heart Assoc
Objective—Ceramides are molecular lipids implicated in apoptosis, inflammation, obesity,
and insulin resistance. An earlier study reported that ceramides were associated with fatal …

Ceramide remodeling and risk of cardiovascular events and mortality

LR Peterson, V Xanthakis, MS Duncan… - Journal of the …, 2018 - Am Heart Assoc
Background Recent studies suggest that circulating concentrations of specific ceramide
species may be associated with coronary risk and mortality. We sought to determine the …

Plasma ceramides: a novel predictor of major adverse cardiovascular events after coronary angiography

JW Meeusen, LJ Donato, SC Bryant… - … , and vascular biology, 2018 - Am Heart Assoc
Objective—Ceramides are sphingolipids involved with cellular signaling. Synthesis of
ceramides occurs in all tissues. Ceramides accumulate within tissues and the blood plasma …

Development and validation of a high-throughput LC–MS/MS assay for routine measurement of molecular ceramides

D Kauhanen, M Sysi-Aho, KM Koistinen… - Analytical and …, 2016 - Springer
Monitoring the levels of the ceramides (Cer) d18: 1/16: 0, Cer d18: 1/18: 0, Cer d18: 1/24: 0,
and Cer d18: 1/24: 1 and ratios thereof in human plasma empowers the prediction of fatal …