Severe sepsis and septic shock represent challenging problems for the health care system.
Despite adequate antibiotics and modern intensive care, severe sepsis is associated with a …

Much research over the past 30 to 40 years has shown that the inflammatory response,
while critical for host defense during microbial infection, may itself play a central role in the …

Sepsis or septic shock is the fourth leading cause of long-stay intensive care admissions.
Death may occur despite antimicrobial therapy. The incidence of mortality from sepsis has …

Sepsis is one of the most common deadly diseases. Despite its remarkable incidence, and
despite the progress which has been made in understanding this complex syndrome, for …

Our understanding of sepsis and its resultant outcomes remains a paradox. On the one
hand, we know more about the pathophysiology of sepsis than ever before. However, this …

Sepsis is defined as severe systemic inflammation in response to invading pathogens, or an
uncontrolled hyperinflammatory response, as mediated by the release of various …

This practically oriented book provides an up-to-date overview of all significant aspects of
the pathogenesis of sepsis and its management, including within the intensive care unit …

Sepsis, defined as an infection accompanied by inflammation, is a complex disease process
wherein the body's response to a pathogen is amplified far beyond the initial site of infection …

Despite a decrease in early mortality, sepsis is still burden with a poor prognosis related to
immunological, cognitive and neuromuscular impairments. The lessons learned from the …

In recent years, the concept has emerged that the host's inflammatory response contributes
substantially to the development of septic shock and organ failure. Experimental …