[HTML][HTML] Molecular pathways involved in COVID-19 and potential pathway-based therapeutic targets

M Farahani, Z Niknam, LM Amirabad… - Biomedicine & …, 2022 - Elsevier
pathways among them. Based on the latest research and hypotheses about SARS-CoV-2
infection, we provide a new perspective of COVID-19 disease, … In acute lung injury caused by …

Ageing mechanisms that contribute to tissue remodeling in lung disease

M Schuliga, J Read, DA Knight - Ageing research reviews, 2021 - Elsevier
… obstructive pulmonary disease (COPD) and certain phenotypes of asthma. The recent COVID-19
… The existence of ageing pathways may also explain why certain pathological changes …

[HTML][HTML] COVID-19 and Lung Mast Cells: The Kallikrein–Kinin Activation Pathway

S Nagashima, AA Dutra, MP Arantes, RC Zeni… - International Journal of …, 2022 - mdpi.com
… Interestingly, this enzyme is also involved in tissue remodeling [52,53]. … COVID-19 compared
to the other groups (Figure 1), thus correlating these cells with the events of acute lung injury

[HTML][HTML] Cellular and molecular pathways of COVID-19 and potential points of therapeutic intervention

JP Hussman - Frontiers in pharmacology, 2020 - frontiersin.org
COVID-19 is a severe acute respiratory disease caused by the novel coronavirus SARS-CoV…
The resulting synthesis enables construction of a coherent biological pathway that suggests …

Lung epithelial and endothelial damage, loss of tissue repair, inhibition of fibrinolysis, and cellular senescence in fatal COVID-19

F D'Agnillo, KA Walters, Y Xiao, ZM Sheng… - Science Translational …, 2021 - science.org
… late-onset pulmonary tissue and vascular remodeling. Acute … fatal influenza in that direct
pulmonary damage due to SARS-… pathways (75), has shown some efficacy against COVID-19 (…

Lung fibrosis: post-COVID-19 complications and evidences

R Hirawat, N Jain, MA Saifi, M Rachamalla… - International …, 2023 - Elsevier
… have discussed several important pathways which are involved in post-COVID PF. Further,
… found, an ideal marker for Interstitial lung disease (ILD) DAD Capillary congestion Interstitial …

The SARS-CoV-2 E protein induces Toll-like receptor 2-mediated neonatal lung injury in a model of COVID-19 viremia that is rescued by the glucocorticoid …

HL Menden, SM Mabry… - … of Physiology-Lung …, 2023 - journals.physiology.org
… in the circulation mediate ALI in COVID-19 remain unclear. We … ALI and lung remodeling
in a model of neonatal COVID-19. … Although the respiratory route is the primary mode of …

The role of cytokines and Molecular pathways in Lung Fibrosis following SARS-CoV-2 infection: a physiopathologic (re) view

M Lazar, M Sandulescu, EC Barbu, CE Chitu-Tisu… - Biomedicines, 2024 - mdpi.com
… with a history of chronic obstructive pulmonary disease [14]. A study … -COVID-19 pulmonary
complications. They contribute to lung tissue remodeling and pulmonary fibrosis after COVID-…

[HTML][HTML] … of extracellular matrix remodelling and wound healing be used to identify high risk patients infected with SARS-CoV-2?: lessons learned from pulmonary …

DJ Leeming, F Genovese, JMB Sand… - Respiratory …, 2021 - Springer
… One route for the loss of functional surfactant is associated with the wound … COVID-19
progression, nevertheless it is well known that lung inflammation and sustained lung damage is …

[HTML][HTML] COVID-19 lung disease shares driver AT2 cytopathic features with Idiopathic pulmonary fibrosis

S Sinha, V Castillo, CR Espinoza, C Tindle… - …, 2022 - thelancet.com
… to be sufficient to drive downstream fibrotic remodeling in the lung. … key disease drivers
(cellular processes, immune pathways, and the signaling cascades that support those pathways). …