The role of IL-6 and other mediators in the cytokine storm associated with SARS-CoV-2 infection

A Copaescu, O Smibert, A Gibson, EJ Phillips… - Journal of Allergy and …, 2020 - Elsevier
… to a hyperinflammatory state (“cytokine storm”) followed by acute respiratory … cytokine storm
in its severest form has been marked by elevation of IL-6, IL-10, TNF-α, and other cytokines

Pathogenic human coronavirus infections: causes and consequences of cytokine storm and immunopathology

R Channappanavar, S Perlman - Seminars in immunopathology, 2017 - Springer
cytokine/chemokine response known as “cytokine storms,” … evidence that “cytokine storms
and immunopathology can … sufficient understanding of the specific factor/s responsible for …

Targeting inflammation and cytokine storm in COVID-19

Q Huang, X Wu, X Zheng, S Luo, S Xu… - Pharmacological Research, 2020 - Elsevier
… the involvement of a cytokine storm [2]. Cytokine storm represents an exaggerated immune
… of pro-inflammatory cytokines and chemokines such as IFN-γ, TNF-α, IL-6, IL-1β, IL-18, …

Cytokine storm and probable role of immunoregulatory drugs in COVID-19: a comprehensive review

A Sadeghzadeh-Bazargan, E Behrangi… - Iranian Journal of …, 2020 - iranjd.ir
… Since there is no specific antiviral treatment for the disease and given the growing amount
of data about the role of the inflammatory response and cytokine storm in increased disease …

Innate immunity, cytokine storm, and inflammatory cell death in COVID-19

R Karki, TD Kanneganti - Journal of Translational Medicine, 2022 - Springer
cytokines and the induction of inflammatory cell death. These processes can contribute to
cytokine storm, … framework for innate immunity driving cytokine storm and organ damage in …

Cytokine storm in COVID-19: An overview, mechanism, treatment strategies, and stem cell therapy perspective

NU Azmi, MU Puteri, D Lukmanto - … Sciences and Research, 2020 - scholarhub.ui.ac.id
… excessive amount of cytokine serum level (cytokine storm) has … Thus, the management of
the cytokine storm could be the … prospective treatment strategies for cytokine storm in COVID-19…

Confronting the controversy: interleukin-6 and the COVID-19 cytokine storm syndrome

LYC Chen, RL Hoiland, S Stukas… - European …, 2020 - Eur Respiratory Soc
… In this editorial, we address these controversies and demonstrate that cytokine storm … of
cytokine storm syndrome Critics of the COVID-CSS concept have claimed that “cytokine storm

COVID-19: Pathogenesis, cytokine storm and therapeutic potential of interferons

SH Nile, A Nile, J Qiu, L Li, X Jia, G Kai - Cytokine & growth factor reviews, 2020 - Elsevier
… interleukin-1 (IL-1), IL-6, IL-18, and interferon-gamma [29]. … patients with cytokine storm
syndrome, IL-6 blockade using anti-… most at risk of dying from Covid-19-induced cytokine storms. …

Weathering the cytokine storm in susceptible patients with severe SARS-CoV-2 infection

B Lipworth, R Chan, S Lipworth… - The Journal of Allergy …, 2020 - jaci-inpractice.org
… A more selective approach is therefore required to address the downstream cytokine storm.
Recent attention has centered around the possibility of therapeutic intervention with anti-IL-6

[HTML][HTML] Cytokine storm in COVID-19: from viral infection to immune responses, diagnosis and therapy

Y Jiang, L Rubin, T Peng, L Liu, X Xing… - … journal of biological …, 2022 - ncbi.nlm.nih.gov
… of proinflammatory cytokines, also known as cytokine storm, … that the occurrence of cytokine
storm in severe acute … events related to excessive cytokine production and inflammatory …