… a subset of patients with schizophrenia who have comorbid … thus far of rare variant data for
schizophrenia, which we jointly … genes disrupted by rare risk variants in schizophrenia and to …

… of schizophrenia. We observe an overlap of rare variant risk among schizophrenia, autism
… that genes prioritized from common variant analyses of schizophrenia are enriched in rare …

… common SNPs and rare CNVs jointly contribute to the risk for schizophrenia. We tested a …
to confer disease risk. This model predicts that individuals with schizophrenia who have large-…

… that common risk variants exist in … rare variants in schizophrenia, and some (but not a
substantial part) of the polygenic contribution that was observed in the International Schizophrenia …

… of rare variant risk factors in individuals with severe, extremely treatment-resistant schizophrenia
suggests future clinical opportunities for risk … studies in schizophrenia and highlight a …

… schizophrenia. We find significant evidence for an overlap of rare variant risk between
schizophrenia, … a neurodevelopmental etiology for schizophrenia. We show that protein-truncating …

… Schizophrenia (SZ) is a disorder with a high heritability and a complex architecture. Several
dozen genetic variants have been identified as risk … However, the bulk of the risk cannot be …

… schizophrenia polygenic risk score was similar between individuals with and without clinically
relevant rare genetic variation; common variants … to clinically relevant rare variant burden, …

… of large, rare deletions may modify the phenotype in those at risk of psychosis: those
possessing such events are more likely to be diagnosed as having schizophrenia, and those …

… We present a pipeline for integrative analysis of trio-based DN variants and CC rare variants,
to infer rare-variant genetic architecture parameters and to identify disease risk genes. We …