… to integrate data from diverse populations, enabling more powerful analyses of … populations
5 . Here, we consider the principles and methods of applying PRSs across global populations…

… the CVD risk score identified 15% of the population above this risk threshold, then we used
the equivalent risk threshold of the Harvard NHANES score to identify 15% of the population. …

… Comparison of the Framingham and Reynolds Risk scores for global cardiovascular risk …
Application in national populations We used the risk score to estimate the 10-year risk of fatal …

… sequence data from global populations with results from … of how disease risks can be
misestimated in global populations, and (3… genetic risk scores that correct for major sources of …

… pressure in all populations. In contrast, other effects on polygenic adaptation or risk
scores, such as long-standing environmental differences across global populations that have …

… risk in a currently healthy population. Equally important, that analysis relied on data from
1712 women who experienced only 68 vascular events, many of which were coded as heart …

… risk factors on having undiagnosed type 2 diabetes differs between populations from different
ethnic origin, and risk scores … of one risk score in nine populations of diverse ethnic origin. …

… in score distributions for global populations. Polygenic … of polygenic risk scores is poorer in
non-European populations, … genetic diversity within many African populations, the phenotypic …

… original risk scores were identified. Risk scores included a median number of 5 risk factors.
… The area under the receiver operating characteristic curve of risk scores ranged from 0.62 to …

… risk scores in individual’s level. In laboratory-based models, agreement across categories
was substantial in the overall population (… substantial for the whole population (kappa values: …