… Through imputation and mixed-model association analysis in 12,577 cases and 23,475 … a
new risk locus on chromosome 21 and identified C21orf2 as a gene associated with ALS risk. …

… to compare the association of each variant with the 2 … variants have stronger associations
with the risk of asthma, whereas the LRRC32 variant has a stronger association with the risk …

… rare variants. In this review, we provide an overview of statistical issues in rare-variant
association … We present the design and analysis pipeline of rare-variant studies and review cost-…

… Very few rare variants-associated with T2D have been identified in previous studies 26,…
variants (0.0001 ≤ MAF < 0.01) in the association analysis in UKB and detected 11 rare variants …

… heightened risk of suicide. We conducted a genome-wide association meta-analysis based
in … were enriched for smaller association signal. We found important relationships of genetic …

… increase as more variance in disease risk is explained by risk variants that are identified.
We release a software package implementing LTSCORE for use in future association studies. …

… analyses suggest that CRC risk is highly polygenic, and larger, more comprehensive studies
enabling rare variant analysis will improve understanding of biology underlying this risk …

… With a marked sample-size increase from a unique Danish population resource, we
report a genome-wide association meta-analysis of 18,381 individuals with ASD and 27,969 …

… consequences of risk variants identified in our study by examining the association between
… Our primary interest in these single nucleotide polymorphism (SNP)-based analyses was to …

… wide significant (GWS) associations were observed for initiation of use 17 or for CAD. Herein
we report on findings for DSM-IV CAD criteria from association analyses performed in large …