Long noncoding RNA Kcnq1ot1 promotes sC5b-9-induced podocyte pyroptosis by inhibiting miR-486a-3p and upregulating NLRP3

C Zhang, Y Gong, N Li, X Liu, Y Zhang… - … of Physiology-Cell …, 2021 - journals.physiology.org
… of miR-486a-3p in Kcnq1ot1 expression, and our findings further demonstrated that Kcnq1ot1
can sponge miR-486a-3p, thus mediating sC5b-9-induced miR-486a-3p downregulation. …

[HTML][HTML] LncRNA kcnq1ot1 promotes lipid accumulation and accelerates atherosclerosis via functioning as a ceRNA through the miR-452-3p/HDAC3/ABCA1 axis

XH Yu, WY Deng, JJ Chen, XD Xu, XX Liu… - Cell Death & …, 2020 - nature.com
… 7C), indicating a direct interaction between the two RNAs. Next, … kcnq1ot1 and HDAC3
shares a common miR-452-3p binding site. Further, miR-452-3p decreased the levels of kcnq1ot1

[HTML][HTML] Knockdown of lncRNA KCNQ1OT1 inhibits glioma progression by regulating miR-338-3p/RRM2

Z Yin, L Liao, S Mao, Y Liu, T Xie, H Yu… - Open Life Sciences, 2020 - degruyter.com
RNA (ceRNA) network of KCNQ1OT1/miR-338-3p/RRM2. To investigate this hypothesis we
measured the expression of KCNQ1OT1 in … KCNQ1OT1/miR-338-3p/RRM2 in glioma cells. …

[HTML][HTML] Silencing long non-coding RNA Kcnq1ot1 limits acute kidney injury by promoting miR-204-5p and blocking the activation of NLRP3 inflammasome

JT Wang, P Jiao, XY Wei, Y Zhou - Frontiers in Physiology, 2021 - frontiersin.org
… Long non-coding RNAs (LncRNAs) are important in AKI. This study aimed to explore the …
Kcnq1ot1 in AKI by sponging microRNA (miR)-204-5p as a competitive endogenous RNA (…

[HTML][HTML] Integrated analysis of the lncRNA-associated competing endogenous RNA network in salt sensitivity of blood pressure

W Peng, Y Xie, J Xia, H Qi, K Liu, B Li, F Zhang, F Wen… - Heliyon, 2023 - cell.com
Accumulating evidence showed that competing endogenous RNA (ceRNA) mechanism
plays a pivotal role in salt sensitivity of blood pressure (SSBP). We constructed a ceRNA …

[HTML][HTML] Silencing long non-coding RNA Kcnq1ot1 alleviates pyroptosis and fibrosis in diabetic cardiomyopathy

F Yang, Y Qin, J Lv, Y Wang, H Che, X Chen… - Cell death & …, 2018 - nature.com
Kcnq1ot1 functioned as a competing endogenous RNA to regulate the expression of caspase-1
by sponging miR-214-3pKcnq1ot1 and miR-214-3p, as well as caspase-1 and miR-214-…

[HTML][HTML] Long non-coding RNA KCNQ1 overlapping transcript 1 promotes the progression of esophageal squamous cell carcinoma by adsorbing microRNA-133b

H Xu, J Miao, S Liu, H Liu, L Zhang, Q Zhang - Clinics, 2021 - SciELO Brasil
… The long non-coding RNA (lncRNA) KCNQ1 overlapping transcript 1 (KCNQ1OT1) exerts
vital regulatory functions in diverse tumors. However, the biological function of KCNQ1OT1 in …

Long noncoding RNA KCNQ1OT1 induces pyroptosis in diabetic corneal endothelial keratopathy

Y Zhang, Z Song, X Li, S Xu, S Zhou… - American Journal of …, 2020 - journals.physiology.org
… of KCNQ1OT1 in diabetic corneal endothelial keratopathy. Here, we reveal that KCNQ1OT1
… showed that KCNQ1OT1 may function as a competing endogenous RNA binding miR-214 …

lncRNA KCNQ1OT1 promotes the proliferation, migration and invasion of retinoblastoma cells by upregulating HIF-1α via sponging miR-153-3p

Y Wang, J Wang, H Hao, X Luo - Journal of Investigative …, 2020 - journals.sagepub.com
… -153-3p and KCNQ1OT1, miR-153-3p and HIF-1α were examined by dual luciferase reporter
gene assay and RNA-… In addition, miR-486-3p and miR-532 are found to be significantly …

[PDF][PDF] Construction of lncRNA regulatory networks reveal the key lncRNAs associated with Pituitary adenomas progression

YH Xue, YQ Ge - Math Biosci Eng, 2020 - aimspress.com
… binding proteins network, and competing endogenous RNA … In lung cancer, KCNQ1OT1
modulated miRNA-27b-3p/… Our study for the first time revealed KCNQ1OT1 may play key …