… The RNA-dependent RNA polymerase (RdRP), a viral enzyme for viral RNA replication
in host cells, is one of the most intriguing and promising drug targets for SARS-CoV-2 drug …

… targets the RNA-dependent RNA polymerase (RdRp), an essential enzyme for viral RNA
replication and a promising drug target for … in complex with substrate RNA and remdesivir were …

… RNA-dependent RNA polymerase (RdRp), also called nsp12, is considered a promising
but challenging drug target for inhibiting replication and hence, the growth of various RNA-…

… Here we review the current status of six RdRp-targeting drugs … these drugs have potential
as therapeutic options against SARS-CoV-2, discovering and developing new drugs targeting …

… drug discovery and/or repositioning against SARS-CoV-2. In the current study, RNA-dependent
RNA polymerase (… , is proposed as a potential therapeutic target to inhibit viral infection. …

… The viral polymerase nsp12 looks an excellent target for new therapeutics, especially given
… This target, in addition to other promising drug targets such as the main protease, whose …

… We have shown that Pol-I inhibition occurs by a p53-, ATM/ATR-, and Top2-independent …
that the drug influences the assembly and stability of preinitiation complexes by targeting the …

… The EV71 genome encodes an RNAdependent RNA polymerase (RdRp), denoted 3Dpol,
which is central for viral genome replication and is a key target for the discovery of specific …

… Recent work has identified a new drug target – the ‘switch region’ – within bacterial RNAP
([10, 11, 12, 13, 14•]; reviewed in [15, 16, 17]). The switch region is a structural element that …

… -guided drug design difficult. Structural studies of the viral RNAdependent-RNA polymerase
(… replication machinery, will set the stage for rational drug design and fill a major gap in our …