… molecular biology, and biochemistry, we show that UK-118005 inhibits RNA polymerase (Pol)
III… Although natural products have been identified that inhibit different RNA Pols, such as α-…

… The bacterial RNA polymerase is a proven target for antimicrobials because it … RNA polymerase
is also a molecular machine that presents numerous targets for small-molecule inhibitors …

… inhibitor of the DENV NS5 RNA-dependent RNA polymerase (RdRp), we performed a
high-throughput screening of a fragment library. We identified RK-0404678 as a potent inhibitor of …

… The RNA-dependent RNA polymerase (RdRp) of noroviruses … as a target for small molecule
inhibitors. Crystal structures of the … , and small-molecule inhibition of norovirus polymerase. …

… assay system in studying RdRp inhibitors, we checked well-known nucleoside analogs
and non-nucleoside inhibitors targeting viral RNA polymerase, including remdesivir, ribavirin, …

… The viral RNA-dependent RNA polymerase (RdRp) activity … Here, we report the identification
of a novel class of inhibitor (ie, … -derived small-molecule inhibitor that targets DENV RdRp …

… selectivity of BMH-21 for Pol I has not been directly measured. Here, we quantify the effects
of BMH-21 on Pol I, RNA polymerase II (Pol II), and RNA polymerase III (Pol III) in vitro using …

… of life involves the synthesis of an RNA molecule from a DNA template. In bacteria,
transcription is catalysed by a multi-subunit RNA polymerase (RNAP). RNAP performs sequence-…

… of identifying specific inhibitors of core–σ interaction. Small molecule inhibitors could serve
as … This is, to our knowledge, the first example of a small molecule inhibitor of this interaction. …

… HTS of the compound collection for inhibition of the HCV RNA dependent RNA polymerase
… by solid phase synthesis to establish initial SAR and identify a potent inhibitor is reported. …