Single-cell RNA sequencing to explore immune cell heterogeneity

E Papalexi, R Satija - Nature Reviews Immunology, 2018 - nature.com
… in studies that aim to deconvolve immune cell heterogeneity, but they can differ by orders of
cellular profiling) and the number of genes per cell that can be detected (the depth of cellular

[HTML][HTML] Dissecting cellular heterogeneity using single-cell RNA sequencing

YH Choi, JK Kim - Molecules and cells, 2019 - Elsevier
… -cell RNA sequencing (scRNA-seq) allows the quantitative and unbiased characterization
of cellular heterogeneity … In this review, we provide an overview of scRNA-seq protocols and …

Biological and medical importance of cellular heterogeneity deciphered by single-cell RNA sequencing

RK Gupta, J Kuznicki - Cells, 2020 - mdpi.com
… in single-cell RNA sequencing (scRNA-seq), which can describe cellular heterogeneity in
various organs, … We outline scRNA-seq techniques that are suitable for investigating cellular

Single cell RNAsequencing: A powerful yet still challenging technology to study cellular heterogeneity

M Ke, B Elshenawy, H Sheldon, A Arora, FM Buffa - Bioessays, 2022 - Wiley Online Library
… types in the multiple myeloma microenvironment that we would not have identified from
traditional bulk RNA sequencing. [ 121 ] scRNA-Seq has been used to identify a new cell

Computational analysis of cell-to-cell heterogeneity in single-cell RNA-sequencing data reveals hidden subpopulations of cells

F Buettner, KN Natarajan, FP Casale, V Proserpio… - Nature …, 2015 - nature.com
… To fully exploit single-cell RNA-seq data, we have to account for the … heterogeneity. Although
the importance of accounting for unobserved factors is well established in bulk RNA-seq

The impact of heterogeneity on single-cell sequencing

SL Goldman, M MacKay, E Afshinnekoo… - Frontiers in …, 2019 - frontiersin.org
… Here, we will outline the importance of cellular heterogeneity, … RNA sequencing here is
key, as transcriptomics captures fine details of non-genetic heterogeneity that other sequencing

Single-cell analyses of transcriptional heterogeneity during drug tolerance transition in cancer cells by RNA sequencing

MCW Lee, FJ Lopez-Diaz, SY Khan… - Proceedings of the …, 2014 - National Acad Sciences
… -cell analyses reveal the dynamics of the stress response in terms of cell-specific RNA variants
driving heterogeneity, … population through generation of specific RNA variants, and the …

Single-cell RNA sequencing reveals the cellular heterogeneity of aneurysmal infrarenal abdominal aorta

G Zhao, H Lu, Z Chang, Y Zhao, T Zhu… - Cardiovascular …, 2021 - academic.oup.com
… In summary, our study revealed the hallmarks of infrarenal aortic cell heterogeneity in an
unbiased manner. Using scRNA-seq, we identified the response signatures of VSMCs and Mo/…

Pan-cancer single-cell RNA-seq identifies recurring programs of cellular heterogeneity

GS Kinker, AC Greenwald, R Tal, Z Orlova, MS Cuoco… - Nature …, 2020 - nature.com
heterogeneous within human tumors. We prioritized specific cell lines as models of cellular
heterogeneity … Our work describes the landscape of heterogeneity within diverse cancer cell

Single-cell RNA-Seq reveals cell heterogeneity and hierarchy within mouse mammary epithelia

H Sun, Z Miao, X Zhang, UI Chan, SM Su, S Guo… - Journal of Biological …, 2018 - ASBMB
… In this study, we applied single-cell RNA-seq to uncover the heterogeneity and differentiation
trajectory of mouse mammary epithelia as well as the novel markers for the MaSCs and …