Immunogenicity of low-dose prime-boost vaccination of mRNA vaccine CV07050101 in non-human primates

N van Doremalen, RJ Fischer, JE Schulz, MG Holbrook… - Viruses, 2021 - mdpi.com
… in small animal models, non-human primates, and human volunteers. In this study, … non-human
primates received a prime-boost intramuscular vaccination with 4 µg of mRNA vaccine

A prefusion SARS-CoV-2 spike RNA vaccine is highly immunogenic and prevents lung infection in non-human primates

AB Vogel, I Kanevsky, Y Che, KA Swanson, A Muik… - BioRxiv, 2020 - biorxiv.org
To contain the coronavirus disease 2019 (COVID-19) pandemic, a safe and effective
vaccine against the new severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is …

An optimized messenger RNA vaccine candidate protects non-human primates from Zika virus infection

B Bollman, N Nunna, K Bahl, CJ Hsiao, H Bennett… - npj Vaccines, 2023 - nature.com
… mRNA-1325 and mRNA-1893 vaccination and reported that mRNA-1893 generated … ZIKV
challenge in non-human primates. In-depth characterization of these vaccines indicated that …

BNT162b vaccines are immunogenic and protect non-human primates against SARS-CoV-2

AB Vogel, I Kanevsky, Y Che, KA Swanson, A Muik… - bioRxiv, 2020 - biorxiv.org
… Messenger RNA technology allows versatile vaccine antigen design and highly scalable, …
, RNA vaccines are highly suited to rapid development and pandemic supply 12, 13 . RNA

mRNA vaccine CVnCoV protects non-human primates from SARS-CoV-2 challenge infection

S Rauch, K Gooch, Y Hall, FJ Salguero, MJ Dennis… - Biorxiv, 2020 - biorxiv.org
… Overall, 8 μg CVnCoV vaccination induced the lowest number of viral RNA copies in the
upper respiratory tract, where median values of 2.9 x 10 6 cp/ml in nasal swabs, respectively, …

An Alphavirus-derived replicon RNA vaccine induces SARS-CoV-2 neutralizing antibody and T cell responses in mice and nonhuman primates

JH Erasmus, AP Khandhar, MA O'Connor… - Science translational …, 2020 - science.org
… the vaccine was capable of inducing strong immune responses in a nonhuman primate
model that more closely resembles humans in the immune response to vaccination. Three …

Single-dose replicating RNA vaccine induces neutralizing antibodies against SARS-CoV-2 in nonhuman primates

JH Erasmus, AP Khandhar, AC Walls, EA Hemann… - bioRxiv, 2020 - biorxiv.org
… if the vaccine was capable of inducing strong immune responses in a nonhuman primate
model that more closely resembles humans in the immune response to vaccination. Three …

Visualization of early events in mRNA vaccine delivery in non-human primates via PET–CT and near-infrared imaging

KE Lindsay, SM Bhosle, C Zurla, J Beyersdorf… - Nature biomedical …, 2019 - nature.com
… of a model messenger RNA vaccine labelled with the probe. After intramuscular administration
of the vaccine to the monkeys, we observed the dynamics of the mRNA vaccine at the …

Nonhuman primates in translational research

AF Tarantal, SC Noctor… - Annual review of …, 2022 - annualreviews.org
… shown, and changes in protein and RNA expression patterns identified, … vaccine research
in nonhuman primates was in some ways a successful forerunner to the SARS-CoV-2 vaccine

A replicon RNA vaccine can induce durable protective immunity from SARS-CoV-2 in nonhuman primates after neutralizing antibodies have waned

MA O'Connor, DW Hawman, K Meade-White… - Plos …, 2023 - journals.plos.org
… COVID-19 vaccines. Here we tested a novel COVID-19 self-amplifying … RNA vaccine in
a nonhuman primate model. We found that various doses of the vaccine and different vaccine