… The compartmental expression of transporters in various tissues plays a critical role in the
drug disposition process. In organs such as the liver and kidney, the coordinated expression …

… They are substrates for drug efflux transporters such as P-glycoprotein (Pgp), multidrug …
or by-passing drug efflux transporters at the BBB as novel therapeutic approaches to drug-…

… in disposal of drug and its clinical efficacy/toxicity, these transporters also play vital roles
in … This chapter will outline classification of drug transporters, their roles in drug disposal/drug …

… transporters that play a crucial role in drug disposition. Explaining the principles of drug
transport and the associated techniques, Drug Transporters: Molecular Characterization and …

… body does to the drug. Drug disposition is a collective term used to describe drug absorption,
distribution, … The role of enzymes in the metabolism of drugs is considered in Section 3.2. …

… of drug disposition through the application of those principles to modern approaches to drug
… There has been increased interest in the roles of active transport and facilitated diffusion in …

… on the impact of transporters on drug disposition is included in summaries of product …
of the role of the drug metabolism–drug transport interplay for drug-drug interactions and on …

… role in excreting xenobiotics and metabolites into urine and bile and into the intestinal
lumen, and in preventing their accumulation in the brain. The roles of Pgp in drug disposition …

… Although, most of the studies have cited the role of Kupffer cell-derived TLRs in hepatic
drug metabolism, we and others have also shown that LPS or LTA treatment of primary mouse …

… We concentrate on the BDDCS and its utility in predicting drug disposition. Furthermore,
we focus on the effect of food on the extent of drug availability (F), which appears to follow …