过去一年中添加的文章,按日期排序

Overview of preclinical and clinical studies investigating pharmacokinetics and drug-drug interactions of padsevonil

H Chanteux, M MacPherson, H Kramer… - … Opinion on Drug …, 2024 - Taylor & Francis
2 天前 - … Overall, integration of all preclinical and clinical studies presented in this article
contributed to understanding the disposition of PSL (role of CYP enzymes) as well as its risk as …

Metabolic characterization of the new benzimidazole synthetic opioids-nitazenes

GR Jadhav, PS Fasinu - Frontiers in Pharmacology - frontiersin.org
10 天前 - … The involvement of multiple polymorphic CYPs in their metabolism may play important
roles in the susceptibility to intoxication and/or addiction, depending on the activity of the …

Therapeutic drug monitoring of antiretroviral therapy: current progresses and future directions

D Cattaneo, C Gervasoni - Expert Review of Clinical Pharmacology, 2024 - Taylor & Francis
26 天前 - … In 2019 we published a narrative review on the role of therapeutic drug monitoring
(TDM) of antiretroviral drugs in the management of people with HIV (PWH) [Citation1]. Since …

Low azithromycin maximal concentrations in patients concomitantly taking rifampicin: time to move away from rifampicin in the treatment of non-tuberculous …

A Gaviraghi, A de Nicolò, F Venuti… - Antimicrobial Agents …, 2024 - Am Soc Microbiol
36 天前 - … We would like to contribute to the ongoing discussion on the role of rifampicin in the
… lacks bactericidal activity, and no adjunctive role in preventing the emergence of resistance …

# 2436 Genetic variability in rosuvastatin metabolism explains rhabdomyolysis and consequent acute renal failure

G Mlinšek, T Blagus, MM Vrečko… - Nephrology Dialysis …, 2024 - academic.oup.com
36 天前 - … high dose rosuvastatin prescribing and of pointing out the role of genetic
variability in drug metabolizing enzymes and transporters (DMET) in rosuvastatin side effects. …

[PDF][PDF] Significance of N-acetyltranseferase-2 (NAT-2) gene polymorphism in the patients of cervical cancer

B Singh, D Nath, R Kumar - floraandfona.org.in
39 天前 - … The findings of this study reveal the role of PCR based genotyping methods in
predicting the occurrence of cervical cancer as well as defining high risk persons. …

PHARMACOKINETIC DRUG-DRUG INTERACTIONS MEDIATED BY ORGANIC CATION TRANSPORTERS: ARE ANTIMALARIAL DRUGS SIGNIFICANTLY …

CO ONYEJI - Universal Journal of Pharmaceutical Research, 2024 - ujpronline.com
45 天前 - … influence drug disposition is important to enable a prediction of pharmacokinetic
drug … on antimalarial pharmacokinetic drug-drug interaction studies in which role of OCTs are …

Predict Non-Targeted Clearance of Therapeutic Antibodies Using a Human FcRn Dependent in vitro Transcytosis Assay

C Szynal - 2024 - dash.harvard.edu
47 天前 - … Non-targeted biological features that guide the disposition of these multispecific …
Fc receptor (FcRn) which plays an important role in serum immunoglobulin (IgG) homeostasis. …

[引用][C] Special Section on Cytochrome P450 Enzymes in Toxicology and as Drug Targets

X Zhong, Y Lai - Drug Metabolism and Disposition, 2024 - ASPET
49 天前 - … As a postdoctoral fellow, she studied the role of cytochrome P450 (P450)-mediated
metabolic activation in the mechanisms of hepatotoxicity associated with the tyrosine kinase …

[HTML][HTML] ABCB1 attenuates brain exposure to the KRASG12C inhibitor opnurasib whereas binding to mouse carboxylesterase 1c influences its plasma exposure

J Rijmers, IA Retmana, V Bui, D Arguedas… - Biomedicine & …, 2024 - Elsevier
49 天前 - … We evaluated the pharmacokinetic roles of the ABCB1 (P-… CES1 in plasma and
tissue disposition of oral opnurasib, using … No significant pharmacokinetic roles of the OATP1 …