… role of various nuclear receptors and transcription factors in the expression of drug disposition
… -mediated regulation of drug metabolizing enzymes and drug transporters. © 2005 Wiley-…

… Here we review the different studies that aim to elucidate the genetic factors influencing
treatment response and drug disposition of oral glucose-lowering medications used in the …

Importance of the field: Delivery of drugs to the retina remains a major challenge which
needs to be addressed urgently because retinal disorders are leading causes of visual …

… In this chapter, we will expand on the role played by P-gp in altering drug disposition,
with particular emphasis on the methodologies used to assess it (see also Chap. 5). …

… The roles presumably played by circadian rhythms in drug metabolising liver enzymes and
kidney function are summarised, and the practical implications of chronopharmacokinetics, …

… caused by transporter-mediated drug–drug interactions (DDIs) or … role of organic anion
transporting polypeptides (OATPs in humans/Oatps in other animal species) in drug disposition…

… roles in drug pharmacokinetics and demonstrated the impact of renal transporters on the
disposition of drugs, drug-drug … and their roles in drug elimination and disposition, drug-induced …

… Drug transporters, drug-metabolizing enzymes, and drug targets each play a distinct and
important role in the drug disposition and … With regard to drug targets, to date, pharmacogenetic …

… a role in drug disposition (Box 3). These include not only numerous DMEs and DTPs, but
also abundant serum binding proteins and regulatory (transcription) factors that control the …

… and pathophysiological changes can affect drug disposition. This is particularly important in
view … Its role is a protective one; it actively transports drugs and xenobiotics back into the gut …