Blood–brain barrier breakdown-inducing astrocytic transformation: novel targets for the prevention of epilepsy

A Friedman, D Kaufer, U Heinemann - Epilepsy research, 2009 - Elsevier
… underlying injury-related epileptogenesis remain unknown. … of the blood–brain barrier (BBB)
during epileptogenesis. Here … potential involvement of primary BBB lesion in epileptogenesis

Albumin induces excitatory synaptogenesis through astrocytic TGF-β/ALK5 signaling in a model of acquired epilepsy following blood–brain barrier dysfunction

I Weissberg, L Wood, L Kamintsky, O Vazquez… - Neurobiology of …, 2015 - Elsevier
… similar epileptogenic effects that are prevented by the specific inhibition of the TGF-β\ALK5
pathway. Our findings validate the role of TGF-β in PIE, supporting the epileptogenic role of …

The roof is leaking and a storm is raging: repairing the blood–brain barrier in the fight against epilepsy

JA Gorter, E Aronica, EA Van Vliet - Epilepsy currents, 2019 - journals.sagepub.com
… Research into the role of the blood–brain barrier (BBB) in epilepsy … epileptogenic brain
tissue. At the same time it has become increasingly clear that (neuro)inflammation may play a role

Blood–brain barrier, epileptogenesis, and treatment strategies in cortical dysplasia

M Kaya, AJ Becker, C Gürses - Epilepsia, 2012 - Wiley Online Library
… This article presents the results of two separate studies on the involvement of blood–brain
barrier (BBB) in epilepsy. The first focuses on the effects of antiepileptic drugs in animal …

Multimodality imaging of blood–brain barrier impairment during epileptogenesis

H Breuer, M Meier, S Schneefeld… - Journal of Cerebral …, 2017 - journals.sagepub.com
… Our findings will help to further evaluate the role of BBB impairment in epileptogenesis
and provide a potential method to optimize timing of BBB protective treatment approaches. …

Does leakage of the blood–brain barrier mediate epileptogenesis?

D Janigro - Epilepsy Currents, 2007 - journals.sagepub.com
… In addition to acute seizures, there is new evidence that inflammation may also play a role
in epileptogenesis, although no antiinflammatory compounds have yet been shown to be …

Evidence implicating blood-brain barrier impairment in the pathogenesis of acquired epilepsy following acute organophosphate intoxication

PN Bernardino, AS Luo, PM Andrew, CM Unkel… - … of Pharmacology and …, 2024 - ASPET
… acute OP intoxication causes BBB impairment and its role in the … blood-brain barrier (BBB)
dysfunction and epileptogenesis; … relationships between BBB dysfunction and epilepsy may …

… treatment influences blood-brain barrier failure associated with angiogenesis and inflammatory responses in the acute phase of epileptogenesis in post-status …

K Itoh, Y Ishihara, R Komori, H Nochi, R Taniguchi… - Brain Research, 2016 - Elsevier
… These results suggested that the relationship between microglia activation and neuronal
cell death in the acute phase of epileptogenesis might play an important role in the …

Epilepsy and alterations of the blood–brain barrier: cause or consequence of epileptic seizures or both?

W Löscher - … and Pathology of the Blood-Brain Barrier, 2020 - Springer
… –brain barrier (BBB) is a dynamic and complex barrier essential for the normal function of …
This led to the concept that epileptogenic brain insults and seizures induce a non-specific “…

Blood–brain barrier leakage during early epileptogenesis is associated with rapid remodeling of the neurovascular unit

M Bankstahl, H Breuer, I Leiter, M Märkel, P Bascuñana… - Eneuro, 2018 - eneuro.org
… subsequent impairment of the NVU, our data support the necessity of a prompt BBB-restoring
treatment as one component of rational therapeutic intervention to prevent epileptogenesis