Epileptiform activity and spreading depolarization in the blood–brain barrier-disrupted peri-infarct hippocampus are associated with impaired GABAergic inhibition …

K Lippmann, L Kamintsky, SY Kim… - Journal of Cerebral …, 2017 - journals.sagepub.com
brain barrier may be associated with spreading depolarizations, seizures, and epileptogenesis
as well as cognitive dysfunction. … We describe changes in the function of the peri-ischemic …

Molecular mechanism involved in the pathogenesis of early-onset epileptic encephalopathy

G Vitaliti, P Pavone, S Marino, MAN Saporito… - Frontiers in molecular …, 2019 - frontiersin.org
… of processes of blood-brain barrier (BBB) disruption and … and prognostication of epileptic
disorders remains yet to be … suggests a crucial role for these cells in epileptogenesis. The …

Synaptic dysfunction in epilepsy

АV Zaitsev, DV Amakhin, AV Dyomina… - Journal of Evolutionary …, 2021 - Springer
… whole entirety of processes observed during epileptogenesis, but focus primarily on current
… regions of the brain, and hence the role they play in the processes of epileptogenesis. In …

Altered vascular permeability but not angiogenesis may play a role in the epileptogenesis of human hippocampal sclerosis

R Mhatre, M Anita, M Phillip, J Saini… - … Disorders, 2021 - Wiley Online Library
… -brain barrier and redistribution of AQP4 were identified which may contribute to
epileptogenesis… This constitutes the largest study in the published literature evaluating a role of …

Exposure to nerve agents: from status epilepticus to neuroinflammation, brain damage, neurogenesis and epilepsy

M de Araujo Furtado, F Rossetti, S Chanda, D Yourick - Neurotoxicology, 2012 - Elsevier
… may play a role on the latent period and epileptogenesis. This review assesses how an
initial acute exposure to NA can induce epilepsy and considers the role played by inflammatory …

Astrocytes as guardians of neuronal excitability: mechanisms underlying epileptogenesis

QP Verhoog, L Holtman, E Aronica… - Frontiers in …, 2020 - frontiersin.org
… We will discuss the role of astrocyte-related processes in epileptogenesis, including … as
blood-brain barrier dysfunction and dysregulation of blood flow. Since dysfunction of astrocytes …

Astrocyte dysfunction in epilepsy

G Seifert, G Carmignoto, C Steinhäuser - Brain research reviews, 2010 - Elsevier
… to play a crucial role in the pathogenesis of this disorder. While … Dysfunction of the blood–brain
barrier (BBB) seems to be … kinase hypothesis of epileptogenesis, which considers this …

Immune mechanism of epileptogenesis and related therapeutic strategies

MJ Aguilar-Castillo, P Cabezudo-García… - Biomedicines, 2022 - mdpi.com
… peripheral level (outside the blood-brain barrier (BBB)) or at … role in the etiopathology of
epilepsy and seizure disorders [… , while others defended a primary role in epileptogenesis [36]. …

Paroxysmal slow cortical activity in Alzheimer's disease and epilepsy is associated with blood-brain barrier dysfunction

DZ Milikovsky, J Ofer, VV Senatorov Jr… - Science Translational …, 2019 - science.org
… BBBd was shown to be a key component in the pathogenesis of epilepsy (epileptogenesis)
in many studies (9–15) with a specific role attributed to the extravasation of serum albumin …

[HTML][HTML] Chronic dysfunction of blood-brain barrier in patients with post-encephalitic/encephalopathic epilepsy

T Kimizu, Y Takahashi, T Oboshi, A Horino, H Omatsu… - Seizure, 2018 - Elsevier
… little effect on BBB function, no or few focal brain lesions on brain MRI, and no history of any
… initiates BBB dysfunction described above would induce widespread epileptogenic lesions. …