… perfused rat liver have been … hepatic transporters involved in hepatic drug elimination
will be briefly reviewed in this article, along with the most important substrates and drug–drug …

… drug elimination and thus an important site for drugdrug interactions (DDIs) apparent at the
level of systemic pharmacokinetics. For instance, the total hepatic clearance … hepatic uptake.…

… The elimination of drugs and metabolites from the liver cell back to the bloodstream is … ,
while the elimination towards the biliary canaliculi is mediated by several different transporters (…

… drugs and endogenous substances. Altered function of hepatic drug transporters due to
drug-drug … Liver plays a critical role in drug metabolism and excretion of substances from the …

… excretion results in an increase in the metabolic clearance … total hepatic clearance, whereas
increases in biliary excretion … excretion of drug is a function of the biliary intrinsic clearance…

… SLC and ABC drug transporters expressed in intestine, liver, and kidney, … elimination of
drugs, this chapter focuses on the general characteristics of the major human drug transporters …

… roles of drug-metabolizing enzymes and transporters in renal drug and chemical elimination
and drug–drug … of the decreased clearance reported for many drugs eliminated by hepatic …

… hepatic cytosol and mediating the excretion of drugs and metabolites from … role of hepatic
transporters in the generation of DILI. Transporter gene polymorphisms and altered transporter …

… in various tissues, including the liver, lung, and kidney. OATP… (45); thus, its importance in
renal drug elimination is currently … the importance of these transporters in renal drug elimination …

… the liver and considered to be of particular importance for hepatic drug elimination and
drug … Recent literature has indicated that inhibition of these transporters may result in drug–drug …