Physiologic role of interleukin-1 receptor antagonist

WP Arend, C Gabay - Arthritis Research & Therapy, 2000 - Springer
Recent studies have described the spontaneous development of arthritis or vasculitis in IL-1
receptor antagonist (IL-1Ra) knockout mice bred on specific and different genetic …

Biological role of interleukin 1 receptor antagonist isoforms

WP Arend, CJ Guthridge - Annals of the rheumatic diseases, 2000 - ard.bmj.com
The interleukin 1 receptor antagonist (IL1Ra) family of molecules now includes one secreted
isoform (sIL1Ra) and three intracellular isoforms (icIL1Ra1, 2, and 3). Extensive evidence …

The role of interleukin-1 in the pathogenesis of rheumatoid arthritis

J Kay, L Calabrese - Rheumatology, 2004 - academic.oup.com
… Human recombinant interleukin 1 stimulates collagenase and … Role of tumor necrosis factor
and interleukin 1 in chronicity and cartilage destruction. Ann Rheum Dis 1999;58(Suppl. 1):…

Correction: The role of interleukin-1 polymorphisms in the pathogenesis of gastric cancer

EM El-Omar, M Carrington, WH Chow, KEL McColl… - Nature, 2001 - nature.com
In this Letter, a statement on page 715 that the eustatic sea level Dzeus (t) differs from the
ice-volume-equivalent sea level Dze (t) is erroneous. We thank WR Peltier for drawing this …

Role of interleukin 1 and interleukin 1 receptor antagonist in the mediation of rheumatoid arthritis

MH Schiff - Annals of the rheumatic diseases, 2000 - ard.bmj.com
interleukin 1 (IL1) has been shown to be a key mediator in the autoimmune disease rheumatoid
arthritis (RA). Interleukin 1Interleukin 1 receptor antagonist (IL1Ra) selectively inhibits …

Interleukin-1 and cancer progression: the emerging role of interleukin-1 receptor antagonist as a novel therapeutic agent in cancer treatment

AM Lewis, S Varghese, H Xu, HR Alexander - Journal of translational …, 2006 - Springer
… Our focus in this review is to summarize the known data on the role of IL-1 in tumor
progression and metastasis and the use of IL-1 inhibition as a novel therapeutic approach in the …

Role of interleukin-1 in the pathogenesis of experimental shigellosis.

PJ Sansonetti, J Arondel, JM Cavaillon… - The Journal of …, 1995 - Am Soc Clin Investig
The effect of human recombinant interleukin-1 receptor antagonist on intestinal inflammation,
tissue destruction, and bacterial invasion during experimental shigellosis caused by …

New roles for interleukin-1 Beta in the mechanisms of epilepsy

A Vezzani, TZ Baram - Epilepsy currents, 2007 - journals.sagepub.com
… disorders, such as ischemic stroke and Alzheimer's disease (1). Insight into the many
faceted roles of the cytokines, especially of interleukin-1 beta (IL-1β), in the initiation and …

[PDF][PDF] Emerging role of interleukin-1 in cardiovascular diseases.

B Vicenová, V Vopálenský, L Burýšek… - Physiological …, 2009 - biomed.cas.cz
Interleukin-1 (IL-1), a master regulator of diverse inflammatory processes in higher … about
the IL-1 signaling pathways and about the implication of IL-1 and the IL-1 receptor antagonist (IL…

The pivotal role of interleukin-1 in the clinical manifestations of rheumatoid arthritis

JM Dayer - Rheumatology, 2003 - academic.oup.com
… Major role for interleukin 1 but not for tumor necrosis factor in … human monocytes of interleukin
1 or an interleukin 1 inhibitor. … A urine inhibitor of interleukin 1 activity that blocks ligand …