Interleukin 1 (IL1) is a primary regulator of inflammatory and immune responses. Via its type
I receptor it activates specific protein kinases, including the NFκB inducing kinase (NIK) and …

… of interleukin 1 (IL-1) influences tumor growth and metastases either through direct
proliferative effects or by promoting inflammatory and angiogenic pathways in host cells (1–4). IL-…

… interleukin 1 release in a dose dependent fashion. We conclude that colonic mucosal interleukin
1 … in active inflammatory bowel disease and may have a role in the pathogenesis of the …

… -1β by the interleukin-1 receptor antagonist (IL-1RA) has demonstrated a central role of IL-1
in a … Induction of circulating interleukin 1 in rabbits in vivo and in human mononuclear cells in …

… , the consensus role of IL-1 in epilepsy. Three lines of evidence suggest a role for IL-1: brain
… shows increased IL-1 expression after seizures, and IL-1 has proconvulsive properties …

… underlie IL-1's function in the setting of acute brain injury, where it has been ascribed potential
roles in repair as well as in exacerbation of damage. Explorations of IL-1's role in chronic …

… is inhibition of interleukin-1 (IL-1), ie IL-1β, which plays a pivotal role in the pathophysiology
of OA.[5] The aim of this review article is to critically appraise the role of IL-1 inhibitors in OA, …

… However, recent evidence suggests that IL-1 may be required for the normal physiological …
the physiological role of IL-1 in learning and memory we examined the induction of IL-1 gene …

… -1 signaling Interleukin-1 (IL-1) is a central molecule in inflammation and immune responses
whose pleiotropic activities are mediated by the type I IL-1 receptor (IL1RI). The IL-1RI …

… IL-1~3 plays a role in hypoxiainduced cell death, we used several methods to prevent IL-1
from binding … Human interleukin 1 is a cytocidal factor for several tumor cell lines.J. Immunol. …