The proinflammatory cytokine interleukin-1 binds to two cell-surface receptors. The type I
receptor, an 80-kDa protein with a cytoplasmic domain of ∼215 amino acids, mediates the …

… Interleukin-1 (IL-1) is a potent inflammatory cytokine that was discovered in the 1970s
and was first described as lymphocyte-activating factor [1,2] or leukocytic pyrogen [3] . It …

… We report here that the expression of interleukin-1β (IL-1β), IL-1β-converting enzyme,
and IL-1 receptor type 1 (IL-1RI) is up-regulated in a murine scrapie model. The scrapie-induced …

… Although IL- 1 is found in placental trophoblasts and appears to play a role in embryonic
development, implantation, and birth, mice deficient in IL-l@, IL-Io converting enzyme (ICE), or IL…

… This factor is active across species lines, does not support the growth of interleukin 2 (IL-2)-…
been termed interleukin 1 (IL-1) 2. More recently, it has become evident that IL-1 activities …

… In most cases, other cytokines are produced in addition to IL-1. Therefore, the data depicted
in Table I reveal that IL-1 plays an important role in the pathogenesis. of inflammatory and …

… In the present study, B-LPS was examined for its ability to induce interleukin 1 (IL-1) production,
a mitogenic response, and macrophage activation in LPS high-responder C3H/HeN and …

Both interleukin-1 (IL-1) and endotoxin (lipopolysaccharide, LPS) are potent activators of the
hypothalamo-pituitary-adrenal (HPA) axis, and they also increase cerebral norepinephrine …

… protein synthesis by murine recombinant interleukin 1 (IL-1) and purified human IL-1. J. Exp.
… The role of interleukin 1 in acute phase serum amyloid A (SAA) and serum amyloid P (SAP) …

… Interleukin-1β (IL-1β), which is assigned a key role in the orchestration of the complex immune
response to infection and injury (1), was originally described as an immune cell mediator …