COVID-19, immune system response, hyperinflammation and repurposingantirheumatic drugs

A Tufan, AA Güler… - Turkish journal of medical …, 2020 - journals.tubitak.gov.tr
COVID-19 might be associated with the excessive production of proinflammatory cytokines
cytokine … The level of lymphocytes and subsets of T cells which play a significant role in the …

Inflammatory Markers and Cytokines in Moderate and Critical Cases of COVID-19.

SH Chang, D Minn, SW Kim, YK Kim - Clinical Laboratory, 2021 - search.ebscohost.com
… Inflammatory responses play an important role in the progression of COVID-19, and several
… in severe COVID-19 [8,12]. A variety of different proinflammatory cytokines and chemokines …

Clinical significance of measuring serum cytokine levels as inflammatory biomarkers in adult and pediatric COVID-19 cases: A review

BM Liu, TB Martins, LK Peterson, HR Hill - Cytokine, 2021 - Elsevier
… of COVID-19 associated cytokines, their roles in host immune and inflammatory responses,
the clinical significance and utility of cytokine … levels of pro-inflammatory cytokines may have …

COVID-19 cytokine storm: The anger of inflammation

M Mahmudpour, J Roozbeh, M Keshavarz, S Farrokhi… - Cytokine, 2020 - Elsevier
… II/AT1R axis might have a pivotal role in the clinical presentations of COVID-19. In fact, higher
… Also, the increased production of C3a leads to production of pro-inflammatory cytokines

COVID-19: Pathogenesis, cytokine storm and therapeutic potential of interferons

SH Nile, A Nile, J Qiu, L Li, X Jia, G Kai - Cytokine & growth factor reviews, 2020 - Elsevier
… the release of pro-inflammatory cytokines and chemokines … importance to use the knowledge
at our disposal to treat those patients most at risk of dying from Covid-19-induced cytokine

NF-κB pathway as a potential target for treatment of critical stage COVID-19 patients

R Kircheis, E Haasbach, D Lueftenegger… - Frontiers in …, 2020 - frontiersin.org
cytokine and chemokine levels, ie cytokine storm, seem to play a central role in severity and
lethality in COVID-19… of whole cascades of pro-inflammatory cytokines and chemokines. The …

… interleukin-10 is a stronger predictor of severe disease and poor outcomes than the pro-inflammatory cytokine response in coronavirus disease 2019 (COVID-19)

BM Henry, SW Benoit, J Vikse, BA Berger… - Clinical Chemistry and …, 2021 - degruyter.com
… Severe coronavirus disease 2019 (COVID-19) is associated … the anti-inflammatory cytokine
response to COVID-19, by … to the role of hyperinflammation in development of COVID-19

An inflammatory cytokine signature predicts COVID-19 severity and survival

DM Del Valle, S Kim-Schulze, HH Huang… - Nature medicine, 2020 - nature.com
… IL-1 is also a highly active pro-inflammatory cytokine, and … IL-8 is a potent pro-inflammatory
cytokine playing a key role in … the role of inflammatory cytokines on COVID-19 disease …

Mechanism of inflammatory response in associated comorbidities in COVID-19

TMC de Lucena, AF da Silva Santos… - Diabetes & Metabolic …, 2020 - Elsevier
… affected by COVID-19 present an uncontrolled release of pro-inflammatory cytokines and
an … improvement of respiratory function and rapid fever control in 21 patients with severe …

COVID-19: Melatonin as a potential adjuvant treatment

R Zhang, X Wang, L Ni, X Di, B Ma, S Niu, C Liu… - Life sciences, 2020 - Elsevier
… There is also a potential repressed immune function in COVID-19 patients with the hypo-…
activated and express a cluster of pro-inflammatory cytokines and chemokines including IL-1β, …