The dual role of tumor necrosis factor-alpha (TNF-α) in breast cancer: molecular insights and therapeutic approaches

D Cruceriu, O Baldasici, O Balacescu… - Cellular Oncology, 2020 - Springer
… breast cancer patients and their respective clinical status and outcome. Secondly, we
emphasize the role of TNF-α signaling in both estrogen-positive and -negative breast cancer cells. …

Divergent roles for tumor necrosis factor-α in the brain

K Sriram, JP O'Callaghan - Journal of Neuroimmune Pharmacology, 2007 - Springer
… Prominent among such factors is the pleiotropic cytokine, tumor necrosis factor (TNF)-α.
Under normal physiological conditions, TNF-α orchestrates a diverse array of functions involved …

The role of Tumor Necrosis Factor-alpha (TNF-α) in the pathogenesis of systemic lupus erythematosus

M Postal, S Appenzeller - Cytokine, 2011 - Elsevier
The Tumor Necrosis Factor-alpha (TNF-α) is a pleiotropic cytokine that produces … TNF-α
contributes importantly to the development of T cells, B cells, and dendritic cells. However, TNF-α

Evidence of a role of tumor necrosis factor α in refractory asthma

MA Berry, B Hargadon, M Shelley… - … England Journal of …, 2006 - Mass Medical Soc
Tumor necrosis factor α (TNF-α) is a pleiotropic inflammatory cytokine … the role of TNF-α in
refractory asthma has been increased by a study showing increased concentrations of TNF-α

Dual role of tumor necrosis factor alpha in brain injury

E Shohami, I Ginis, JM Hallenbeck - Cytokine & growth factor reviews, 1999 - Elsevier
… It induces increased production of tumor necrosis factor (TNFα) by brain resident cells. There
is conflicting evidence on the role of this response in the injured brain, showing its potential …

Role of tumor necrosis factoralpha in rheumatoid arthritis: a review

P Vasanthi, G Nalini… - APLAR Journal of …, 2007 - Wiley Online Library
Tumor necrosis factor-alpha (TNF-α) is a proinflammatory cytokine that plays a pivotal role
… Although it is controversial whether TNF-α genes are associated with RA susceptibility, they …

[HTML][HTML] The role of tumor necrosis factor-alpha in systemic lupus erythematosus

M Aringer, JS Smolen - Arthritis research & therapy, 2008 - Springer
Tumor necrosis factor (TNF) exerts a variety of physiologic and pathogenic effects [1–6].
For example, TNF plays a major role in the organogenesis of the lymphoid system in early …

Role of tumor necrosis factor-α in disease states and inflammation

RM Strieter, SL Kunkel, RC Bone - Critical care medicine, 1993 - journals.lww.com
Objective: To review the animal and human data defining the role of tumor necrosis factor (TNF)
in the pathogenesis of the septic shock syndrome, the systemic inflammatory response …

Essential role of tumor necrosis factor α (TNF-α) in tumor promotion as revealed by TNF-α-deficient mice

M Suganuma, S Okabe, MW Marino, A Sakai… - Cancer research, 1999 - AACR
… To examine the hypothesis that tumor necrosis factor (TNF) α is an essential cytokine in …
-dimethylbenz(a)anthracene (DMBA), plus either of two tumor promoters, okadaic acid and 12-O-…

[HTML][HTML] The role of tumor necrosis factor alpha (TNF-α) in autoimmune disease and current TNF-α inhibitors in therapeutics

D Jang, AH Lee, HY Shin, HR Song, JH Park… - International journal of …, 2021 - mdpi.com
Tumor necrosis factor alpha (TNF-α) was initially recognized as a factor that causes the
necrosis of tumors, but it has been recently identified to have additional important functions as a …