Efficacy and safety of dapagliflozin in heart failure with reduced ejection fraction according to age: insights from DAPA-HF

FA Martinez, M Serenelli, JC Nicolau, MC Petrie… - Circulation, 2020 - Am Heart Assoc
… spectrum of age studied in DAPA-HF. There was no significant imbalance in tolerability
or … the efficacy and safety of dapagliflozin according to age in a post hoc analysis of DAPA-HF. …

The Dapagliflozin and Prevention of Adverse‐outcomes in Heart Failure (DAPAHF) trial: baseline characteristics

…, DAPAHF Committees and Investigators - European journal of …, 2019 - Wiley Online Library
… treatment were eligible for DAPA-HF, which is comparing dapagliflozin 10 mg once daily
to … Consequently, DAPA-HF will test the incremental efficacy and safety of dapagliflozin in …

Effect of dapagliflozin in patients with HFrEF treated with sacubitril/valsartan: the DAPA-HF trial

SD Solomon, PS Jhund, BL Claggett, P Dewan… - Heart failure, 2020 - jacc.org
safety of dapagliflozin in patients who were or were not taking sacubitril/valsartan at baseline
in the DAPA-HF (Study to Evaluate the Effect of Dapagliflozin … and safety of dapagliflozin in …

Efficacy and safety of dapagliflozin according to aetiology in heart failure with reduced ejection fraction: insights from the DAPAHF trial

JH Butt, JC Nicolau, S Verma… - European journal of …, 2021 - Wiley Online Library
… analysis of DAPA-HF, we investigated the efficacy and safety of dapagliflozin compared
with … In this pre-specified analysis of DAPA-HF, dapagliflozin reduced the risk of the primary …

Efficacy of dapagliflozin on renal function and outcomes in patients with heart failure with reduced ejection fraction: results of DAPA-HF

PS Jhund, SD Solomon, KF Docherty, HJL Heerspink… - Circulation, 2021 - Am Heart Assoc
… the safety and efficacy of dapagliflozin in patients with HFrEF, according to baseline kidney
function, in the DAPA-HF trial (Dapagliflozin … We also examined the effect of dapagliflozin on …

Efficacy and safety of dapagliflozin in heart failure with reduced ejection fraction according to N-terminal pro-B-type natriuretic peptide: insights from the DAPA-HF trial

JH Butt, C Adamson, KF Docherty… - Circulation: Heart …, 2021 - Am Heart Assoc
… Our findings in DAPA-HF were qualitatively similar to those in PARADIGM-HF with the most
marked benefit in patients with the lowest baseline NT-proBNP, and there was a nominally …

Efficacy and safety of dapagliflozin according to frailty in heart failure with reduced ejection fraction: a post hoc analysis of the DAPA-HF trial

JH Butt, P Dewan, B Merkely, J Belohlávek… - Annals of internal …, 2022 - acpjournals.org
… of dapagliflozin on clinical outcomes in DAPA-HF were independent of baseline frailty class.
Specifically, dapagliflozin, … reduced the risk for worsening HF or cardiovascular death to a …

Effect of dapagliflozin according to baseline systolic blood pressure in the Dapagliflozin and Prevention of Adverse Outcomes in Heart Failure trial (DAPA-HF)

M Serenelli, M Böhm, SE Inzucchi, L Køber… - European heart …, 2020 - academic.oup.com
… We evaluated the efficacy and safety of dapagliflozin, which lowers systolic blood pressure
(SBP),according to baseline SBP in Dapagliflozin and Prevention of Adverse Outcomes in …

Dapagliflozin and diuretic use in patients with heart failure and reduced ejection fraction in DAPA-HF

AM Jackson, P Dewan, IS Anand, J Bělohlávek… - Circulation, 2020 - Am Heart Assoc
… of dapagliflozin in DAPA-HF were obtained regardless of the use of background diuretic
therapy or dose of diuretic therapy. Likewise, the tolerability and safety profile of dapagliflozin

Efficacy and safety of dapagliflozin in patients with type 2 diabetes and concomitant heart failure

M Kosiborod, I Gause-Nilsson, J Xu… - Journal of diabetes and …, 2017 - Elsevier
… The overall safety profile of dapagliflozin in this analysis was comparable to that of the
placebo group, with similar frequencies of AEs occurring in both groups of patients. While renal …