New decade, old debate: blocking the cytokine pathways in infection-induced cytokine cascade

MS Rizvi, AG De Moraes - Critical Care Explorations, 2021 - journals.lww.com
… inhibitors to tackle sepsis and/or ARDS—conditions with a more profound systemic release
of cytokines than the so-called “cytokine storm” of severe and critical COVID-19 ( 2 ). We …

Targeting Specific Checkpoints in the Management of SARS-CoV-2 Induced Cytokine Storm

A Rabiu Abubakar, R Ahmad, AB Rowaiye, S Rahman… - Life, 2022 - mdpi.com
cytokines known as cytokine storm syndrome. This article reported the various checkpoints
targeted to manage the SARS-CoV-2-induced cytokine storm. The … and cytokine storm were …

Suppression of cytokine storm with a sphingosine analog provides protection against pathogenic influenza virus

KB Walsh, JR Teijaro, PR Wilker… - Proceedings of the …, 2011 - National Acad Sciences
… infection include robust cytokine production (cytokine storm), … particular concern because
person-to-person transmission of … At these same time points, mean fluorescence intensity (MFI) …

Excitotoxicity (immunoexcitotoxicity) as a critical component of the cytokine storm reaction in pulmonary viral infections, including SARS-CoV-2

RL Blaylock - International Journal of Vaccine Theory, Practice, and …, 2021 - mail.ijvtpr.com
… occurs in the cytokine storm reaction— immunoexcitotoxicity—in the same manner that we
… by microglia and astrocytes, and these same cytokines can stimulate insertion of certain …

Adiposity induces lethal cytokine storm after systemic administration of stimulatory immunotherapy regimens in aged mice

A Mirsoian, MN Bouchlaka, GD Sckisel… - Journal of Experimental …, 2014 - rupress.org
cytokines TNF, IL-6, and IFN-γ, indicative of a cytokine storm (Fig. … therapy incurred a similar
cytokine storm that culminated in rapid … lower levels of cytokines and demonstrated complete …

Cytokine storm plays a direct role in the morbidity and mortality from influenza virus infection and is chemically treatable with a single sphingosine-1-phosphate …

MBA Oldstone, H Rosen - … -1-Phosphate Signaling in Immunology and …, 2014 - Springer
… result of cytokine storm. This chapter visits primarily influenza virus infection and resultant
cytokine storm. It provides the compelling evidence that illuminates cytokine storm in influenza …

[PDF][PDF] Blocking the Deadly Cytokine Storm is a Vital Weapon for Treating COVID-19

AS Poltorak - civicresearchinstitute.com
… Here’s how an overreaction from the immune system can endanger a person fighting off an
same cytokines is uncontrolled, immunologists describe the situation as a “cytokine storm.” …

Developing cytokine storm-sensitive therapeutic strategy in COVID-19 using 8P9R chimeric peptide and soluble ACE2

Y Nazerian, K Vakili, A Ebrahimi… - Frontiers in Cell and …, 2021 - frontiersin.org
cytokine storm in a precision way by using sensitivity to a critical inflammatory factor (NF-κB)
in each person … In other words, two different goals are being pursued at the same time: (1) …

Mesenchymal stem cell derived-exosomes as effective factors in reducing cytokine storm symptoms of COVID-19

AH Kheirkhah, SH Shahcheraghi… - Protein and Peptide …, 2021 - ingentaconnect.com
… As a member of the genus Corona beta, SARS-CoV-2 may have the same escape …
cytokine storms, immunosuppressive exosomes can be used to control cytokine storms [51-…

[HTML][HTML] RS-5645 attenuates inflammatory cytokine storm induced by SARS-CoV-2 spike protein and LPS by modulating pulmonary microbiota

T Liu, J Wu, C Han, Z Gong, G La Regina… - … journal of biological …, 2021 - ncbi.nlm.nih.gov
… inflammatory storm manifested within an infected person's body has not yet been reported. …
subcutaneously with U87MG cells, the same compound significantly inhibited tumor growth, …