Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor

J Lan, J Ge, J Yu, S Shan, H Zhou, S Fan, Q Zhang… - nature, 2020 - nature.com
… that the SARS-CoV-2 RBD–ACE2 and SARS-CoV RBD–ACE2 … , although some of the
ACE2 interactions observed both inside … of the SARS-CoV-2 and SARS-CoV RBD structures to …

ACE2: the major cell entry receptor for SARS-CoV-2

F Scialo, A Daniele, F Amato, L Pastore, MG Matera… - Lung, 2020 - Springer
… for COVID-19. Here, we focus our attention on ACE2, a primary receptor of SARS-CoV-2. We
… to be employed by SARS-CoV-2 for cell entry. Particular attention will be given to how the …

[HTML][HTML] ACE2, much more than just a receptor for SARS-COV-2

L Samavati, BD Uhal - Frontiers in cellular and infection microbiology, 2020 - frontiersin.org
… The virus gains entrance into its host cell via the ACE2 receptor. How the known epidemiological
and clinical manifestation of SARS-CoV-2 … of the ACE2 receptor due to receptor virus

Human ACE2 receptor polymorphisms and altered susceptibility to SARS-CoV-2

K Suryamohan, D Diwanji, EW Stawiski… - Communications …, 2021 - nature.com
… involved in the SARS-CoV-2 S-protein interaction. Overall, we found human ACE2 receptor
… and the ACE2 PD showed even more reduced variation (Wilcoxon p-value = 0.0656, n = 65, …

Expression of the SARS-CoV-2 ACE2 Receptor in the Human Airway Epithelium

H Zhang, MR Rostami, PL Leopold… - American journal of …, 2020 - atsjournals.org
… From this data, we conclude that the ACE2 receptor for SARS-CoV-2 is distributed throughout
the lung epithelial surface and that the site of infection would be dictated by the size of the …

Physiological and pathological regulation of ACE2, the SARS-CoV-2 receptor

Y Li, W Zhou, L Yang, R You - Pharmacological research, 2020 - Elsevier
ACE2 was identified as the receptor of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2),
the coronavirus … evidence that ACE2 is the receptor for SARS-CoV-2. Results in …

The pivotal link between ACE2 deficiency and SARS-CoV-2 infection

P Verdecchia, C Cavallini, A Spanevello… - European journal of …, 2020 - Elsevier
… Angiotensin converting enzyme-2 (ACE2) receptors mediate the entry into the cell of three
strains of coronavirus: SARS-CoV, NL63 and SARS-CoV-2. ACE2 receptors are ubiquitous …

Human ACE2 receptor polymorphisms predict SARS-CoV-2 susceptibility

EW Stawiski, D Diwanji, K Suryamohan, R Gupta… - BioRxiv, 2020 - biorxiv.org
… of the polymorphisms on receptor recognition by the SARS-CoV-2 RBD and to confirm …
ACE2 variants using the recently published cryo-EM and crystal structures of ACE2/SARS-CoV-2

[HTML][HTML] Structural basis of receptor recognition by SARS-CoV-2

J Shang, G Ye, K Shi, Y Wan, C Luo, H Aihara, Q Geng… - Nature, 2020 - nature.com
… the ACE2-binding affinity among SARS-CoV-2, SARS-CoV … of the SARS-CoV-2 RBM that
result in tight ACE2 binding. They … the structural basis of ACE2 recognition by SARS-CoV-2, we …

A model of the ACE2 structure and function as a SARS-CoV receptor

P Prabakaran, X Xiao, DS Dimitrov - Biochemical and biophysical research …, 2004 - Elsevier
… glycoproteins (Env) with receptors [9], we propose a possible mechanism of the ACE2
function as a receptor for the SARS virus. The analysis of the ACE2 model could also help in the …