SARS-CoV-2 antiviral therapy

K Tao, PL Tzou, J Nouhin, H Bonilla… - Clinical microbiology …, 2021 - Am Soc Microbiol
… effective antiviral therapy for COVID-19 is … antiviral therapies for COVID-19, including
research spanning preclinical and clinical drug development efforts, with an emphasis on antiviral

Potential antiviral options against SARS-CoV-2 infection

A Ianevski, R Yao, MH Fenstad, S Biza, E Zusinaite… - Viruses, 2020 - mdpi.com
SARS-CoV-2 strains from COVID-19 patients in Norway. We showed that UVC and high
temperatures destroyed SARS-CoV-2, … We developed a neutralization assay using SARS-CoV-2

Antivirals against coronaviruses: candidate drugs for SARS-CoV-2 treatment?

IA Santos, VR Grosche, FRG Bergamini… - Frontiers in …, 2020 - frontiersin.org
… hundred percent” effective antiviral therapy against SARS-CoV-2/COVID-19 and that further
… , which may not be based on a unique drug but rather on a combination of active antivirals. …

Antiviral activities of type I interferons to SARS-CoV-2 infection

E Mantlo, N Bukreyeva, J Maruyama, S Paessler… - Antiviral research, 2020 - Elsevier
… identify antivirals to curtail the COVID-19 pandemic. Herein, we report the sensitivity of
SARS-CoV-2 … These results suggest that SARS-CoV-2 is more sensitive than many other human …

Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing

L Riva, S Yuan, X Yin, L Martin-Sancho, N Matsunaga… - Nature, 2020 - nature.com
… Specifically, we assessed the potential antiviral activity of 11,987 compounds against
SARS-CoV-2 in Vero E6 cells. The assay, conducted at a final compound concentration of 5 μM …

A comparative analysis of remdesivir and other repurposed antivirals against SARSCoV2

A Simonis, SJ Theobald, G Fätkenheuer… - EMBO molecular …, 2021 - embopress.org
… drugs with antiviral effects against SARSCoV2 in cell‐based assays as those substances
offer great opportunities for a treatment early in the course of COVID19 by inhibition of viral …

Clinical trials of repurposed antivirals for SARS-CoV-2

MA Martinez - Antimicrobial agents and chemotherapy, 2020 - Am Soc Microbiol
COVID-19 (6). However, the administration of a potent and specific antiviral against SARS-CoV-2
and prior to viral peak could actually stop or avoid the pathogenic course of COVID-19. …

A Comparative Analysis of SARS-CoV-2 Antivirals Characterizes 3CLpro Inhibitor PF-00835231 as a Potential New Treatment for COVID-19

M de Vries, AS Mohamed, RA Prescott… - Journal of …, 2021 - Am Soc Microbiol
… Here, we report the potent antiviral activity of PF-00835231 against SARS-CoV-2 in human
lung epithelial cells and a model of polarized human airway epithelial cultures (HAEC). In our …

[HTML][HTML] Oral antivirals for the prevention and treatment of SARS-CoV-2 infection

V Soriano, C De-Mendoza, B Edagwa, A Treviño… - AIDS …, 2022 - ncbi.nlm.nih.gov
COVID-19 variant. Thus, there is a race to find treatment alternatives. We contend that oral
small molecule antivirals that halt SARS-CoV-2 … is required, oral antivirals offer treatments in …

Current status of antivirals and druggable targets of SARS CoV-2 and other human pathogenic coronaviruses

A Artese, V Svicher, G Costa, R Salpini… - Drug Resistance …, 2020 - Elsevier
… for SARS-CoV-2 infection. … antiviral strategies targeting viral protease, RdRp and spike
glycoprotein, that have been proposed to cope with the infection sustained by SARS-CoV-2 and …