Broad host range of SARS-CoV-2 predicted by comparative and structural analysis of ACE2 in vertebrates

J Damas, GM Hughes, KC Keough… - Proceedings of the …, 2020 - National Acad Sciences
host range of SARS-CoV-2 and predict a broader group of species that may serve as a reservoir
or intermediate host(s) for this virus… at potential risk for SARS-CoV-2 infection based on …

Broad host range of SARS-CoV-2 and the molecular basis for SARS-CoV-2 binding to cat ACE2

L Wu, Q Chen, K Liu, J Wang, P Han, Y Zhang, Y Hu… - Cell discovery, 2020 - nature.com
… interact with SARS-CoV-2 RBD comparing to human ACE2 (hACE2). The results in this study
illustrated the broad range of species whose ACE2s could bind to SARS-CoV-2, including …

Functional and genetic analysis of viral receptor ACE2 orthologs reveals a broad potential host range of SARS-CoV-2

Y Liu, G Hu, Y Wang, W Ren, X Zhao… - Proceedings of the …, 2021 - National Acad Sciences
… -2 entry. Our data demonstrate that an evolutionarily diverse set of ACE2 species variants …
SARS-CoV-2 entry, suggesting that SARS-CoV-2 has a broad host range at the level of virus

Potential host range of multiple SARS-like coronaviruses and an improved ACE2-Fc variant that is potent against both SARS-CoV-2 and SARS-CoV-1

Y Li, H Wang, X Tang, D Ma, C Du, Y Wang, H Pan… - BioRxiv, 2020 - biorxiv.org
… useful experimental model of COVID-19. We show that SARS-CoV-2 and SARS-CoV-1 entry
… -1), infect mammals and have broad host ranges spanning bats, rodents, domestic animals, …

SARS-CoV-2 spike protein predicted to form complexes with host receptor protein orthologues from a broad range of mammals

SD Lam, N Bordin, VP Waman, HM Scholes… - Scientific reports, 2020 - nature.com
SARS-CoV-2 can infect a broad range of mammals, but few fish, birds or reptiles. Susceptible
animals could serve as reservoirs of the virus… the host range and infectivity of SARS-CoV-2. …

Receptor utilization of angiotensin‐converting enzyme 2 (ACE2) indicates a narrower host range of SARSCoV2 than that of SARSCoV

Q Wang, Y Qiu, JY Li, CH Liao… - Transboundary and …, 2021 - Wiley Online Library
… to speculate that SARS-CoV-2 has a broader host range. … that SARS-CoV and SARS-CoV-2
could use a wide variety of … of various mammals to SARS-CoV-2 infection (Shi et al., 2020). …

SARS-CoV-2 variants of concern alpha, beta, gamma and delta have extended ACE2 receptor host ranges

N Thakur, G Gallo, J Newman… - Journal of General …, 2022 - microbiologyresearch.org
… Our previous data indicated that SARS-CoV-2 was a ‘generalist’ with a broad host range [7].
Significantly, the VOCs have even broader host ranges and, in the majority of cases, the …

[HTML][HTML] ACE2 partially dictates the host range and tropism of SARS-CoV-2

S Gao, L Zhang - Computational and Structural Biotechnology Journal, 2020 - Elsevier
… assays of ACE2 from various species, Liu et al. characterized 44 ACE2 orthologs from 49
species that could mediate SARS-CoV-2 entry, suggesting a broad host range of this novel …

Evolution of immune evasion and host range expansion by the SARS-CoV-2 B. 1.1. 529 (Omicron) variant

W Ren, Y Zhang, J Rao, Z Wang, J Lan, K Liu, X Zhang… - MBio, 2023 - Am Soc Microbiol
… of mice becoming reservoirs for SARS-CoV-2, and the virus could potentially spill back to …
the host range should be closely monitored along with the continued evolution of SARS-CoV-2

The potential intermediate hosts for SARS-CoV-2

J Zhao, W Cui, B Tian - Frontiers in microbiology, 2020 - frontiersin.org
… In order to provide information and motivate brainwave for investigators, we will
summarize and analyze up-to-date findings of the potential hosts of SARS-CoV-2 (Figure 1). …