[HTML][HTML] Identification of human single-domain antibodies against SARS-CoV-2

Y Wu, C Li, S Xia, X Tian, Y Kong, Z Wang, C Gu… - Cell host & …, 2020 - cell.com
… Panning this library against SARS-CoV-2 RBD and S1 subunit identified fully human
single-domain antibodies targeting five distinct epitopes on SARS-CoV-2 RBD with subnanomolar …

Anti-SARS-CoV-2 receptor-binding domain antibody evolution after mRNA vaccination

A Cho, F Muecksch, D Schaefer-Babajew, Z Wang… - Nature, 2021 - nature.com
… syndrome coronavirus 2 (SARS-CoV-2) … potent antibodies that are resistant to mutations
found in variants of concern 1 . As a result, vaccination of coronavirus disease 2019 (COVID-19) …

Single-domain antibodies for the detection of SARS-CoV-2 nucleocapsid protein

GP Anderson, JL Liu, TJ Esparza, BT Voelker… - Analytical …, 2021 - ACS Publications
… expressed variable domains derived from camelid heavy-chain antibodies known as single-…
heavy-chain antibody variable domains. After two rounds of panning on SARS-CoV-2 N, we …

Single-domain antibodies efficiently neutralize SARS-CoV-2 variants of concern

IA Favorskaya, DV Shcheblyakov… - Frontiers in …, 2022 - frontiersin.org
… To identify SARS-CoV-2 neutralizing single-domain antibodies we immunized one Bactrian
camel with SARS-CoV-2 RBD. The recombinant RBD protein was previously produced in …

Humanized single domain antibodies neutralize SARS-CoV-2 by targeting the spike receptor binding domain

X Chi, X Liu, C Wang, X Zhang, X Li, J Hou… - Nature …, 2020 - nature.com
… Neutralizing antibodies provide efficient blockade for viral … SARS-CoV-2 spike receptor-binding
domain (RBD) as a bait, we generate a panel of humanized single domain antibodies (…

Structural basis for SARS-CoV-2 nucleocapsid protein recognition by single-domain antibodies

Q Ye, S Lu, KD Corbett - Frontiers in immunology, 2021 - frontiersin.org
… -domain antibodies that bind the SARS-CoV-2 Nucleocapsid protein with high affinity. Each
… of three single-domain antibodies bound to defined domains of the SARS-CoV-2 N protein. …

The role of single-domain antibodies (or nanobodies) in SARS-CoV-2 neutralization

A Zebardast, P Hosseini, A Hasanzadeh… - Molecular Biology …, 2022 - Springer
… nanobodies as a new class of recombinant antibodies in COVID-19 treatment. … domain
counterparts [39, 40]. The first adult medication developed based on the single-domain antibody (…

Discovery and multimerization of cross-reactive single-domain antibodies against SARS-like viruses to enhance potency and address emerging SARS-CoV-2 variants

SA Hollingsworth, CL Noland, K Vroom, A Saha… - Scientific Reports, 2023 - nature.com
… , we have identified single domain antibodies (VHHs) … (SARS-CoV, SARS-CoV-2, and
MERS). Importantly, a number of these antibodies show sub-nanomolar potency towards all SARS-…

Slaying SARS-CoV-2 one (single-domain) antibody at a time

TF Czajka, DJ Vance, NJ Mantis - Trends in microbiology, 2021 - cell.com
… the receptor-binding domain (RBD) of the SARS-CoV-2 Spike protein. We … antibodies
in the global fight against COVID-19. The highly contagious novel coronavirus, SARS-CoV-2

Broad neutralization of SARS-CoV-2 variants by an inhalable bispecific single-domain antibody

C Li, W Zhan, Z Yang, C Tu, G Hu, X Zhang, W Song… - Cell, 2022 - cell.com
domain recognized by broadly neutralizing antibodies. Furthermore, we generated a
bispecific single-domain antibody … these two regions on a single Omicron variant receptor-binding …