R Yan, Y Zhang, Y Li, L Xia, Y Guo, Q Zhou - Science, 2020 - science.org
… COVID-19) epidemic. Here, we present cryo–electron microscopy structures of full-length humanACE2 … spike glycoprotein (S protein) of SARS-CoV-2, both at an overall resolution of 2.9 …
… , compared to the one of the Bat-CoV to this receptor. The data presented in … SARS-Cov-2 spike protein to the humanACE2 receptor, compared to the one of Bat-CoV spike and ACE2. …
M Hussain, N Jabeen, F Raza, S Shabbir… - Journal of medical …, 2020 - Wiley Online Library
… by different humanACE2 allelic variants with SARS-CoV-2 spike protein. Briefly, coding variants of ACE2 corresponding to the reported binding sites for its attachment with coronavirus …
… Here, we show that clinical grade hrsACE2 reduced SARS-CoV-2 recovery from Vero cells … that SARS-CoV-2 can directly infect engineered human blood vessel organoids and human …
… humans who have been hospitalized. Here, we evaluate transgenic mice expressing the human angiotensin I-converting enzyme 2 (ACE2) … a model of SARS-CoV-2 infection. Intranasal …
… In this paper we considered the interaction of S proteins with humanACE2 by combining coarse-grained and all-atom steered molecular dynamics (SMD) simulations. All-atom models …
KK Chan, D Dorosky, P Sharma, SA Abbasi, JM Dye… - Science, 2020 - science.org
… of ACE2 are also being explored as cell entry inhibitors (34). Because humanACE2 has not evolved to recognize SARS-CoV-2 S, … The coding sequence of full-length ACE2 with an N-…
W Li, C Zhang, J Sui, JH Kuhn, MJ Moore, S Luo… - The EMBO …, 2005 - embopress.org
… SARScoronavirus (SARS‐CoV). Here we identify the SARS‐CoV spike (S)‐protein‐binding site on ACE2… S proteins of SARS‐CoV isolated during the 2002–2003 SARS outbreak and …
… SARS-CoV-2 betacoronavirus uses its highly glycosylated trimeric Spike protein to bind to the cell surface receptor angiotensin converting enzyme 2 (ACE2… version of humanACE2. We …