Structural and functional basis of SARS-CoV-2 entry by using human ACE2

Q Wang, Y Zhang, L Wu, S Niu, C Song, Z Zhang, G Lu… - Cell, 2020 - cell.com
… domain of SARS-CoV-2 (SARS-CoV-2-CTD) spike (S) protein in complex with human ACE2
(… binding mode similar overall to that observed for SARS-CoV. However, atomic details at the …

Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2

R Yan, Y Zhang, Y Li, L Xia, Y Guo, Q Zhou - Science, 2020 - science.org
COVID-19) epidemic. Here, we present cryo–electron microscopy structures of full-length
human ACE2 … spike glycoprotein (S protein) of SARS-CoV-2, both at an overall resolution of 2.9 …

[HTML][HTML] Role of changes in SARS-CoV-2 spike protein in the interaction with the human ACE2 receptor: An in silico analysis

JT Ortega, ML Serrano, FH Pujol, HR Rangel - EXCLI journal, 2020 - ncbi.nlm.nih.gov
… , compared to the one of the Bat-CoV to this receptor. The data presented in … SARS-Cov-2
spike protein to the human ACE2 receptor, compared to the one of Bat-CoV spike and ACE2. …

Structural variations in human ACE2 may influence its binding with SARSCoV2 spike protein

M Hussain, N Jabeen, F Raza, S Shabbir… - Journal of medical …, 2020 - Wiley Online Library
… by different human ACE2 allelic variants with SARS-CoV-2 spike protein. Briefly, coding
variants of ACE2 corresponding to the reported binding sites for its attachment with coronavirus

[HTML][HTML] Inhibition of SARS-CoV-2 infections in engineered human tissues using clinical-grade soluble human ACE2

V Monteil, H Kwon, P Prado, A Hagelkrüys, RA Wimmer… - Cell, 2020 - cell.com
… Here, we show that clinical grade hrsACE2 reduced SARS-CoV-2 recovery from Vero cells
… that SARS-CoV-2 can directly infect engineered human blood vessel organoids and human

SARS-CoV-2 infection of human ACE2-transgenic mice causes severe lung inflammation and impaired function

ES Winkler, AL Bailey, NM Kafai, S Nair… - Nature …, 2020 - nature.com
humans who have been hospitalized. Here, we evaluate transgenic mice expressing the
human angiotensin I-converting enzyme 2 (ACE2) … a model of SARS-CoV-2 infection. Intranasal …

Does SARS-CoV-2 bind to human ACE2 more strongly than does SARS-CoV?

HL Nguyen, PD Lan, NQ Thai, DA Nissley… - The Journal of …, 2020 - ACS Publications
… In this paper we considered the interaction of S proteins with human ACE2 by combining
coarse-grained and all-atom steered molecular dynamics (SMD) simulations. All-atom models …

Engineering human ACE2 to optimize binding to the spike protein of SARS coronavirus 2

KK Chan, D Dorosky, P Sharma, SA Abbasi, JM Dye… - Science, 2020 - science.org
… of ACE2 are also being explored as cell entry inhibitors (34). Because human ACE2 has not
evolved to recognize SARS-CoV-2 S, … The coding sequence of full-length ACE2 with an N-…

Receptor and viral determinants of SARScoronavirus adaptation to human ACE2

W Li, C Zhang, J Sui, JH Kuhn, MJ Moore, S Luo… - The EMBO …, 2005 - embopress.org
SARS coronavirus (SARSCoV). Here we identify the SARSCoV spike (S)‐protein‐binding
site on ACE2… S proteins of SARSCoV isolated during the 2002–2003 SARS outbreak and …

Virus-receptor interactions of glycosylated SARS-CoV-2 spike and human ACE2 receptor

P Zhao, JL Praissman, OC Grant, Y Cai, T Xiao… - Cell host & …, 2020 - cell.com
SARS-CoV-2 betacoronavirus uses its highly glycosylated trimeric Spike protein to bind to the
cell surface receptor angiotensin converting enzyme 2 (ACE2… version of human ACE2. We …