… than other SARS-CoV-2 genes. Here I show that ORF8 is poorly conserved among related
coronaviruses. The ORF8 phylogeny built using 11,113 SARS-CoV-2 sequences revealed …

… We generated SARS-CoV-2 ORF8 protein by expression in Escherichia coli and oxidative
refolding. The structure of SARS-CoV-2 ORF8 was determined by X-ray crystallography at a …

… milder Covid-19 phenotype associated to the SARS-CoV-2 ORF8 gene full deletion and
the functions ascribed to the SARS-CoV-2 ORF8 … the ORF8 potential as hotspot of SARS-CoV-2 …

… syndrome coronavirus 2 (SARS-CoV-2) attributed to its ORF8 … the ORF8 protein, a
comprehensive study of the ORF8 protein … Chemical and structural properties of ORF8 proteins …

… coronavirus pathobiology. Here, we analyze certain genomic characteristics of SARS-CoV-2
accessory protein ORF8 … other features of ORF8 and ORF8ab, its homolog from SARS-CoV. …

… coronavirus in animals. These mutations, regardless of their effects on ORF8 itself, can influence
the biology of SARS-CoV-2 … , and diagnostics against this coronavirus (Chan et al., 2020…

… It has been reported that some coronavirus proteins play an important … on SARS-CoV-2. In
this study, we screened the viral proteins of SARS-CoV-2 and found that the viral ORF6, ORF8 …

… We report that SARS-CoV-2 utilizes its ORF8 protein as a unique … of the pathogenesis of
SARS-CoV-2 and will provide additional … and function of T cell antiviral immunity in COVID-19. …

… As ORF3b and ORF8 showed the lowest homology to previous SARS-CoV among all the …
and ORF8 (Fig. 2k). Again, the ORF3b + ORF8 sum showed all patients with COVID-19 had a …

… of the SARS-CoV-2 ORF8 construct used in this study is shown top panel. The ORF8-specific …
Below is a cartoon representation of the monomer with the ORF8-specific region colored …