TG Flower, CZ Buffalo, RM Hooy… - Proceedings of the …, 2021 - National Acad Sciences
… We generated SARS-CoV-2ORF8 protein by expression in Escherichia coli and oxidative refolding. The structure of SARS-CoV-2ORF8 was determined by X-ray crystallography at a …
L Zinzula - Biochemical and biophysical research communications, 2021 - Elsevier
… milder Covid-19 phenotype associated to the SARS-CoV-2ORF8 gene full deletion and the functions ascribed to the SARS-CoV-2ORF8 … the ORF8 potential as hotspot of SARS-CoV-2 …
… syndrome coronavirus2 (SARS-CoV-2) attributed to its ORF8 … the ORF8 protein, a comprehensive study of the ORF8 protein … Chemical and structural properties of ORF8 proteins …
… coronavirus pathobiology. Here, we analyze certain genomic characteristics of SARS-CoV-2 accessory protein ORF8 … other features of ORF8 and ORF8ab, its homolog from SARS-CoV. …
A Valcarcel, A Bensussen, ER Álvarez-Buylla… - Frontiers in …, 2021 - frontiersin.org
… coronavirus in animals. These mutations, regardless of their effects on ORF8 itself, can influence the biology of SARS-CoV-2 … , and diagnostics against this coronavirus (Chan et al., 2020…
JY Li, CH Liao, Q Wang, YJ Tan, R Luo, Y Qiu, XY Ge - Virus research, 2020 - Elsevier
… It has been reported that some coronavirus proteins play an important … on SARS-CoV-2. In this study, we screened the viral proteins of SARS-CoV-2 and found that the viral ORF6, ORF8 …
Y Zhang, Y Chen, Y Li, F Huang… - Proceedings of the …, 2021 - National Acad Sciences
… We report that SARS-CoV-2 utilizes its ORF8 protein as a unique … of the pathogenesis of SARS-CoV-2 and will provide additional … and function of T cell antiviral immunity in COVID-19. …
A Hachim, N Kavian, CA Cohen, AWH Chin… - Nature …, 2020 - nature.com
… As ORF3b and ORF8 showed the lowest homology to previous SARS-CoV among all the … and ORF8 (Fig. 2k). Again, the ORF3b + ORF8 sum showed all patients with COVID-19 had a …
TG Flower, CZ Buffalo, RM Hooy, M Allaire, X Ren… - Biorxiv, 2020 - ncbi.nlm.nih.gov
… of the SARS-CoV-2ORF8 construct used in this study is shown top panel. The ORF8-specific … Below is a cartoon representation of the monomer with the ORF8-specific region colored …