SARS-CoV-2 infection induces a pro-inflammatory cytokine response through cGAS-STING and NF-κB

CJ Neufeldt, B Cerikan, M Cortese, J Frankish… - Communications …, 2022 - nature.com
pro-inflammatory cytokines, specifically IL-6, and lacked type I/III IFNs. We also demonstrate
that SARS-CoV-2 … by SARS-CoV-2 infection, leading to a specific NF-κB response and that …

Does high cardiorespiratory fitness confer some protection against proinflammatory responses after infection by SARSCoV2?

H Zbinden‐Foncea, M Francaux, L Deldicque… - …, 2020 - Wiley Online Library
… Whether a high level of cardiorespiratory fitness can reduce the early amplified proinflammatory
responses in patients infected with SARS-CoV-2 and confer some protective effect …

SARS-CoV-2 exacerbates proinflammatory responses in myeloid cells through C-type lectin receptors and Tweety family member 2

Q Lu, J Liu, S Zhao, MFG Castro, M Laurent-Rolle… - Immunity, 2021 - cell.com
proinflammatory responses. Our findings suggest that SARS-CoV-2-myeloid receptor …
promote immune hyperactivation, which represents potential targets for COVID-19 therapy. …

Attenuated interferon and proinflammatory response in SARS-CoV-2–infected human dendritic cells is associated with viral antagonism of STAT1 phosphorylation

D Yang, H Chu, Y Hou, Y Chai, H Shuai… - The Journal of …, 2020 - academic.oup.com
response in moDCs and MDMs. In addition, while SARS-CoV-2 triggered significant
proinflammatory … MDMs, the proinflammatory response in moDCs upon SARS-CoV-2 infection was …

[HTML][HTML] Systemic pro-inflammatory response identifies patients with cancer with adverse outcomes from SARS-CoV-2 infection: the OnCovid Inflammatory Score

GM Dettorre, S Dolly, A Loizidou, J Chester… - … for ImmunoTherapy of …, 2021 - ncbi.nlm.nih.gov
… better understand the disease biology of SARS-CoV-2 infection. Our work ties a dysfunctional
proinflammatory response to poorer outcomes from COVID-19 in cancer and validates the …

HIF-1α promotes SARS-CoV-2 infection and aggravates inflammatory responses to COVID-19

M Tian, W Liu, X Li, P Zhao, MA Shereen… - … and Targeted Therapy, 2021 - nature.com
SARS-CoV-2-induced cytokine storm is critical for COVID-19 control. Here, we identify that
SARS-CoV-2 … roles in the virus infection and pro-inflammatory responses. RNA sequencing …

CD169-mediated restrictive SARS-CoV-2 infection of macrophages induces pro-inflammatory responses

S Jalloh, J Olejnik, J Berrigan, A Nisa, EL Suder… - PLoS …, 2022 - journals.plos.org
… of pro-inflammatory responses. These findings suggest that induction of pro-inflammatory
responses in SARS-CoV-2-… to the hyperimmune phenotype and pathophysiology of COVID-19. …

The roles of critical proinflammatory cytokines in the drive of cytokine storm during SARSCoV2 infection

MS Qudus, M Tian, S Sirajuddin, S Liu… - Journal of Medical …, 2023 - Wiley Online Library
… Current knowledge of cytokine and chemokine secretions resulting from host immunological
responses to SARS-CoV-2 infection, cytokine storm (CS), and related therapeutic …

SARS-CoV-2 infection induces a long-lived pro-inflammatory transcriptional profile

JY Zhang, JP Whalley, JC Knight, LS Wicker, JA Todd… - Genome Medicine, 2023 - Springer
… pandemic has led to unprecedented collaborative efforts to elucidate the mechanisms of
the immune response to SARS-CoV-2 infection and the development of clinical symptoms in …

Inflammasomes and SARS-CoV-2 infection

J Kaivola, TA Nyman, S Matikainen - Viruses, 2021 - mdpi.com
… -specific function of AIM2 in regulation of Influenza A virus-stimulated proinflammatory
response [36]. These results suggested that AIM2 inflammasome plays a critical role in …